Kim Hyun Yul, Lee Seungju, Kim Dong-Il, Jung Chang Shin, Kim Jee Yeon, Nam Kyung Jin, Choo Ki Seok, Jung Youn Joo
Department of Surgery, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Gyeongnam 50612, South Korea.
Department of Pathology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Gyeongnam 50612, South Korea.
World J Clin Cases. 2022 May 26;10(15):4964-4970. doi: 10.12998/wjcc.v10.i15.4964.
Metaplastic breast cancer (MBC) is a rare subtype of breast cancer. They constitute less than 1% of breast cancer cases and are much rarer in males. There are few reports of MBC because of its rarity. MBC, an aggressive type of cancer, is refractory to common treatment modalities of breast cancer and has a poor prognosis.
We report a case of MBC in a 78-year-old man. He visited our clinic with a palpable mass on the left breast with no masses in the axillary areas. He had previously undergone robot-assisted laparoscopic radical prostatectomy for prostate cancer, but there was no family history of malignancy. The breast mass was visible on ultrasonography, mammography, and magnetic resonance imaging, and chest computed tomography revealed a lung mass in the posterior basal segment of the right lower lobe. The patient was diagnosed with metaplastic carcinoma on core needle biopsy with lung metastasis. Total mastectomy with sentinel lymph node biopsy and video-assisted segmentectomy of the right lung was performed. However, multiple metastases appeared 3 mo after surgery in the brain, chest, and abdomen, and the patient died 5 mo after the initial diagnosis.
MBC is an aggressive and extremely rare breast cancer type. Further case reports are needed to determine the optimal treatment.
化生性乳腺癌（MBC）是一种罕见的乳腺癌亚型。它们占乳腺癌病例的比例不到1%，在男性中更为罕见。由于其罕见性，关于MBC的报道很少。MBC是一种侵袭性癌症，对乳腺癌的常见治疗方式具有耐药性，预后较差。
我们报告一例78岁男性的MBC病例。他因左侧乳房可触及肿块前来我院就诊，腋窝区域未触及肿块。他曾因前列腺癌接受机器人辅助腹腔镜根治性前列腺切除术，但无恶性肿瘤家族史。乳房肿块在超声、乳腺X线摄影和磁共振成像中均可见，胸部计算机断层扫描显示右下叶后基底段有一个肺部肿块。经粗针活检确诊为化生性癌伴肺转移。行全乳切除术加前哨淋巴结活检及右肺电视辅助节段切除术。然而，术后3个月脑、胸、腹出现多处转移，患者在初诊后5个月死亡。
MBC是一种侵袭性极强的罕见乳腺癌类型。需要更多的病例报告来确定最佳治疗方案。
