Katz Heather, Jafri Hassaan, Dougherty Thomas, Lebowicz Yehuda
Department of Oncology, Joan C Edwards School of Medicine at Marshall University, Huntington, West Virginia, USA.
Department of Internal Medicine, Joan C Edwards School of Medicine at Marshall University, Huntington, West Virginia, USA.
BMJ Case Rep. 2018 Mar 7;2018:bcr-2017-222033. doi: 10.1136/bcr-2017-222033.
Metaplastic breast cancer (MBC) in men is an extremely rare entity. MBC is typically very aggressive with a poor prognosis. In men, it has only been reported three times in the literature. We report a 47-year-old man who presented with right-sided breast erythema and nipple inversion. Mammogram revealed a 2.4 cm spiculated mass. Initial pathology was inconclusive; however, right-sided simple mastectomy showed invasive metaplastic carcinoma with adenosquamous histology. He received adjuvant chemotherapy with 4 cycles of dose dense Adriamycin and cyclophosphamide followed by 12 weeks of paclitaxel and chest wall radiation. Although oestrogen receptor status was 1%, tamoxifen was not given due to recent diagnosis of pulmonary embolism. Two years after treatment, he is currently living with no signs of recurrence. This case will serve as a useful addition to the current literature discussing successful diagnosis, treatment and prognosis of a man with MBC.
男性化生性乳腺癌（MBC）是一种极其罕见的疾病。MBC通常具有很强的侵袭性，预后较差。在男性中，文献仅报道过3例。我们报告1例47岁男性，表现为右侧乳房红斑和乳头内陷。乳房X线检查显示一个2.4厘米的毛刺状肿块。初始病理检查结果不明确；然而，右侧单纯乳房切除术显示为具有腺鳞组织学特征的浸润性化生性癌。他接受了辅助化疗，给予4个周期的密集剂量阿霉素和环磷酰胺，随后进行12周的紫杉醇治疗及胸壁放疗。尽管雌激素受体状态为1%，但由于近期诊断为肺栓塞，未给予他莫昔芬治疗。治疗两年后，他目前生活状态良好，无复发迹象。该病例将为当前讨论男性MBC成功诊断、治疗和预后的文献增添有用内容。
