Zhang Yuan-Yao, Meng Zhong-Ji
Postgraduate Training Basement of Jinzhou Medical University, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei Province, China.
Institute of Biomedical Research, Hubei Key Laboratory of Embryonic Stem Cell Research, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei Province, China.
World J Clin Cases. 2022 May 26;10(15):4717-4725. doi: 10.12998/wjcc.v10.i15.4717.
Patients with chronic liver diseases (CLDs) develop acute liver injury and/or acute decompensation under the attack of various precipitants and present with significantly elevated alanine aminotransferase and/or total bilirubin levels, liver failure, or acute decompensation of liver cirrhosis, which is called acute-on-CLD (AoCLD). AoCLD accounts for the majority of patients hospitalized in the Department of Hepatology or Infectious Diseases. AoCLD is complicated by various clinical types, the severity of the disease, and may pose a high risk of death. To date, the definition of AoCLD is still vague, and a consensus concept of the clinical classification is lacking. This review aimed to define the concept and clinical types of AoCLD based on related studies and the literature.
慢性肝病（CLD）患者在各种诱因的作用下发生急性肝损伤和/或急性失代偿，表现为丙氨酸转氨酶和/或总胆红素水平显著升高、肝衰竭或肝硬化急性失代偿，这被称为慢性肝病急性发作（AoCLD）。AoCLD占肝病科或感染科住院患者的大多数。AoCLD有多种临床类型，病情严重，可能导致高死亡风险。迄今为止，AoCLD的定义仍不明确，缺乏临床分类的共识概念。本综述旨在根据相关研究和文献确定AoCLD的概念和临床类型。
