Alarfaj Sumaiah J, Abdallah Mostafa Sally, Abdelsalam Ramy A, Negm Walaa A, El-Masry Thanaa A, Hussein Ismail A, El Nakib Ahmed Mohamed
Department of Pharmacy Practice, College of Pharmacy, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Front Med (Lausanne). 2022 Jun 17;9:902255. doi: 10.3389/fmed.2022.902255. eCollection 2022.
The relationship between () infection and Portal hypertensive gastropathy (PHG) is still a debatable matter. The aim of this study is to find out how common infection is in cirrhotic patients with PHG and to see if there's a link between infection and PHG severity. Out of 340 cirrhotic patients who had upper Gastrointestinal Tract (GIT) endoscopy for early varices screening, 160 cirrhotic patients were selected and divided into 2 groups; 80 cirrhotic patients with PHG (cases) and 80 cirrhotic patients without PHG (controls). Gastric biopsies were taken from all enrolled patients for histological evaluation for the presence or absence of infection. was found in 44 cirrhotic patients (55%) who had PHG (cases), compared to 22 cirrhotic patients (27.5%) who did not have PHG (controls). The prevalence of infection was significantly higher in patients with PHG ( < 0.001). The severity of PHG was associated with infection ( < 0.001). The response to eradication therapy of infection was must better in patients without PHG ( = 0.045). By multi-variant analysis, infection, splenic diameter, and portal vein diameter were independent predictors for PHG presence. After treating infection in patients who tested positive for , there was a significant reduction in PHG severity ( < 0.001). Patients with PHG have a greater prevalence of infection. PHG is more severe in patients infected with . To improve PHG severity, cirrhotic patients must have their infection eradicated.
（）感染与门静脉高压性胃病（PHG）之间的关系仍然是一个有争议的问题。本研究的目的是了解感染在患有PHG的肝硬化患者中有多常见，并查看感染与PHG严重程度之间是否存在关联。在340例因早期静脉曲张筛查而接受上消化道（GIT）内镜检查的肝硬化患者中，选择了160例肝硬化患者并将其分为两组；80例患有PHG的肝硬化患者（病例组）和80例未患有PHG的肝硬化患者（对照组）。对所有入选患者进行胃活检，以进行组织学评估，查看是否存在感染。在患有PHG的44例肝硬化患者（病例组，占55%）中发现了感染，相比之下，在未患有PHG的22例肝硬化患者（对照组，占27.5%）中发现了感染。PHG患者中感染的患病率显著更高（<0.001）。PHG的严重程度与感染相关（<0.001）。未患有PHG的患者对感染根除治疗的反应要好得多（=0.045）。通过多变量分析，感染、脾直径和门静脉直径是PHG存在的独立预测因素。在对检测呈阳性的患者进行感染治疗后，PHG严重程度显著降低（<0.001）。患有PHG的患者感染的患病率更高。感染的患者中PHG更严重。为了改善PHG的严重程度，肝硬化患者必须根除感染。
