Patel Milan K, Trombly Melanie I, Kurt-Jones Evelyn A
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Methods Mol Biol. 2012;921:205-7. doi: 10.1007/978-1-62703-005-2_23.
Innate immune receptors detect Helicobacter pylori infection and trigger downstream signaling events that result in the production of cytokines and interferon-β. This chapter gives an overview of the receptors and their roles in responding to H. pylori infection and details the downstream signaling events. The tools that have been developed to study the innate immune response to H. pylori are also discussed. Understanding the immune response to H. pylori is critical to develop better treatments for H. pylori-induced disease states including gastric malignancies and cancer.
固有免疫受体可检测幽门螺杆菌感染并触发下游信号转导事件，进而导致细胞因子和干扰素-β 的产生。本章概述了这些受体及其在应对幽门螺杆菌感染中的作用，并详细阐述了下游信号转导事件。同时还讨论了为研究针对幽门螺杆菌的固有免疫反应而开发的工具。了解对幽门螺杆菌的免疫反应对于开发针对幽门螺杆菌诱导的疾病状态（包括胃部恶性肿瘤和癌症）的更好治疗方法至关重要。
