Academy of Scientific and Industrial Research (AcSIR), Ghaziabad-201002, India.
Natural Product & Medicinal Chemistry, CSIR-Indian Institute of Integrative Medicine, Jammu-180001, India.
Chem Commun (Camb). 2022 Jul 28;58(61):8508-8511. doi: 10.1039/d2cc02892a.
A photoredox approach enabling one-step synthesis of oxazetidines with a free -NH group the combined use of alkyne, thiophenol, and azide has been reported. The synthesized oxazetidine with the free -NH group was stable enough for various late-stage transformations such as methylation, acetylation, tosylation, and ring-opening reaction to afford synthetically useful α-aminoketones.
一种光氧化还原方法实现了带有游离-NH 基团的恶唑烷的一步合成，该方法结合了炔烃、噻酚和叠氮化物的使用。带有游离-NH 基团的合成恶唑烷足够稳定，可以进行各种后期转化，如甲基化、乙酰化、对甲苯磺酰化和开环反应，以提供合成有用的α-氨基酮。
