Department of Medical Pharmacology and Toxicology, Montpellier University Hospital, Montpellier, France.
Department of Medical data, Health Care Processes and Cost Analysis Unit, Montpellier University Hospital, Montpellier, France.
Fundam Clin Pharmacol. 2022 Dec;36(6):1128-1132. doi: 10.1111/fcp.12815. Epub 2022 Jul 22.
In France, the abuse/misuse of psychoactive substances, including cocaine, is monitored via spontaneous notifications, and under-reporting is its main limitation. Therefore, the French national hospital discharge database (Programme de Médicalisation des Systèmes d'information [PMSI]) was used to identify all hospital stays possibly due to complications related to cocaine use. The objective was to determine the main trends in the rate of cocaine-related hospitalizations from 2010 to 2019 by age category and by areas. Relevant PMSI data were extracted using the International Classification of Diseases (10th edition). In France, hospitalizations for cocaine-related complications increased by fourfold (2461 in 2010, 9843 in 2019, +300%). This increase was similar in men and women and was observed in each age category. Patients were mainly men (75% in 2010 and in 2019), with a median age of 38.5 and 35.2 years for men and women, respectively, in 2019. Cocaine poisoning in pediatric patients (0-9 years) concerned less than 10 patients in 2010 and 21 patients in 2019. PMSI data analysis shows an overall increase of cocaine-related hospitalizations in France from 2010 to 2019 that can be linked in part to an increasing recreational use. The increase of pediatric cases of cocaine poisoning suggests a trivialization of cocaine consumption.
在法国，包括可卡因在内的精神活性物质的滥用/误用情况通过自发报告进行监测，但报告不足是其主要限制。因此，利用法国国家医院出院数据库（Programme de Médicalisation des Systèmes d'information [PMSI]）来确定所有可能因与可卡因使用相关的并发症而住院的病例。目的是确定 2010 年至 2019 年按年龄组和地区划分的与可卡因相关的住院率的主要趋势。使用国际疾病分类（第十版）提取相关 PMSI 数据。在法国，与可卡因相关并发症的住院率增加了四倍（2010 年为 2461 例，2019 年为 9843 例，增加了 300%）。这种增长在男性和女性中都相似，并且在每个年龄组中都观察到。患者主要是男性（2010 年和 2019 年分别为 75%），男性和女性的中位年龄分别为 38.5 岁和 35.2 岁。2010 年仅不到 10 例 0-9 岁儿童患者因可卡因中毒住院，2019 年则为 21 例。PMSI 数据分析显示，2010 年至 2019 年法国与可卡因相关的住院人数总体呈上升趋势，这部分可以归因于娱乐性使用的增加。可卡因中毒儿童病例的增加表明可卡因消费的淡化。
