Division of Immunology and Allergy, University of Health Sciences, Ankara Atatürk Sanatory Education And Research Hospital, Ankara, Turkey.
Department of Endocrinology, Faculty of Medicine, Cukurova University, Adana, Turkey.
Gynecol Endocrinol. 2022 Aug;38(8):666-671. doi: 10.1080/09513590.2022.2096876. Epub 2022 Jul 8.
Although modified Ferriman-Gallwey (mF-G) scorring has been the gold standard for assessing hirsutism, also known that this scorring could show variability according to ethnicity. Hence, false positive hirsutism diagnosis and unnecessary anti-androgen therapy can prescribed. It was aimed to disclose the regional characteristics of this scorring in healthy women living in Southern Turkey.360 women between 18 and 50 years of age were randomly screened. Their medical history, including ovulation periods, gestation(s), family history, known drug use was obtained. Physical examination with mF-G scoring and serum hormone measurements were performed. Women with hirsutism who scored ≥ 8 were further investigated for any underlying disease or cause of hirsutism. After these investigations, the women were divided into three groups according to the mF- ≥ 8 score and evaluated. Group A ( = 59) had an mF- ≥ 8 and, revealed an underlying disease causing hirsutism; group B ( = 42) had an mF- ≥ 8, but no underlying disease responsible for hirsutism; and the third group (Group C, = 259) had an mF- ≤ 8 and thus, no signs of hirsutism.The mean mF-G scores of three groups were 12.78 ± 4.4, 11.48 ± 4.6, and 5.53 ± 3.4, respectively. Of the 59 (16.1%) women in Group A, 46 (44.2%) were diagnosed as polycystic ovary syndrome (PCOS), 8 (7.7%) had idiopathic hyperandrogenism, 7 (6.7%) had nonclassic congenital adrenal hyperplasia, and 1 (1%) had a prolactinoma. When compared to group B, group A women had significantly decreased fertility ( = .001) and menstrual irregularities ( = .001).In this study, results revealed a significant rate of healthy women (11.6%) who had an mF- ≥ 8, but no underlying disease causing hirsutism yet were considered hirsute according to their mF-G cutoff. Also, the majority of the studied women (71.9%) living in Southern Turkey were found to have a hair-pattern similar to the European Women. Therefore, we suggest that regional and ethnical body-hair patterns should be considered before prescribing anti-androgen therapy.
虽然改良的 Ferriman-Gallwey（mF-G）评分被认为是评估多毛症的金标准，但也已知这种评分可能因种族而异。因此，可能会出现假阳性多毛症诊断和不必要的抗雄激素治疗。本研究旨在揭示生活在土耳其南部的健康女性中这种评分的区域性特征。随机筛选了 360 名 18 至 50 岁的女性。获取了她们的病史，包括排卵周期、妊娠史、家族史和已知的药物使用情况。进行了体格检查和 mF-G 评分以及血清激素测量。mF-G 评分≥8 的多毛症患者进一步调查任何潜在疾病或多毛症的原因。在这些调查之后，根据 mF-≥8 评分将这些女性分为三组并进行评估。A 组（=59）mF-≥8，且存在导致多毛症的潜在疾病；B 组（=42）mF-≥8，但无导致多毛症的潜在疾病；第三组（C 组，=259）mF-≤8，因此无多毛症迹象。三组的平均 mF-G 评分分别为 12.78±4.4、11.48±4.6 和 5.53±3.4。在 A 组的 59 名（16.1%）女性中，46 名（44.2%）被诊断为多囊卵巢综合征（PCOS），8 名（7.7%）为特发性高雄激素血症，7 名（6.7%）为非典型先天性肾上腺增生，1 名（1%）为催乳素瘤。与 B 组相比，A 组女性的生育力显著下降（=0.001）和月经不规律（=0.001）。在这项研究中，结果显示，有相当比例的健康女性（11.6%）mF-≥8，但没有导致多毛症的潜在疾病，但根据 mF-G 截止值被认为是多毛症。此外，研究中大多数（71.9%）生活在土耳其南部的女性被发现毛发模式与欧洲女性相似。因此，我们建议在开具抗雄激素治疗之前，应考虑区域性和种族性身体毛发模式。
