Itoh E, Takiguchi H, Shimizu A, Wako N, Ueno H, Chigasaki H, Ishii S
No To Shinkei. 1987 Mar;39(3):227-33.
Effects of a continuous infusion of glycerol on the hypoxic rat were assessed by measurements of local cerebral glucose utilization and local cerebral blood flow using the quantitative autoradiographic 1-[C-14]-2-deoxyglucose and [C-14]-iodoantipyrine techniques, respectively. Local cerebral glucose utilization of the hypoxic rat was decreased in most of cerebral structures except for the amygdala, septal nucleus and the white matter. Local cerebral glucose utilization of the hypoxic rat treated with glycerol was recovered to the pattern of normal control, although glucose utilization of the nucleus raphe and locus ceruleus was accelerated. Cerebral blood flow of the hypoxic rat was elevated in almost of all measured structures. In particular, blood flow in the substantia nigra and locus ceruleus was increased significantly. The pattern of local cerebral blood flow of the hypoxic rat treated with glycerol was more analogous to that of normal control than of hypoxic rat without treatment. It is suggested that glycerol has beneficial effects by elevating local cerebral glucose utilization inhibited and decreasing local cerebral blood flow overshot on the hypoxic condition.
通过分别使用定量放射自显影1-[C-14]-2-脱氧葡萄糖和[C-14]-碘安替比林技术测量局部脑葡萄糖利用和局部脑血流量，评估持续输注甘油对缺氧大鼠的影响。除杏仁核、隔核和白质外，缺氧大鼠的大部分脑结构中的局部脑葡萄糖利用均降低。用甘油治疗的缺氧大鼠的局部脑葡萄糖利用恢复到正常对照模式，尽管中缝核和蓝斑的葡萄糖利用加速。缺氧大鼠几乎所有测量结构中的脑血流量均升高。特别是，黑质和蓝斑中的血流量显著增加。用甘油治疗的缺氧大鼠的局部脑血流模式比未治疗的缺氧大鼠更类似于正常对照。提示甘油通过提高缺氧状态下受抑制的局部脑葡萄糖利用和降低过度的局部脑血流量而产生有益作用。
