Grome J J, Hofmann W, Gojowczyk G, Stefanovich V
Hoechst Marion Roussel, Frankfurt am Main, Germany.
Brain Res. 1996 Nov 18;740(1-2):41-6. doi: 10.1016/s0006-8993(96)00353-8.
The effects of the xanthine derivative propentofylline [3-methyl-1-(5'-oxohexyl)-7-propylxanthine] were measured on local cerebral blood flow and glucose utilization in the rat using quantitative autoradiographic techniques. A dose of 0.5 mg/kg/min i.v. produced increases in local cerebral blood flow and minimal effects on glucose utilization in the majority of cerebral structures measured. A higher dose of propentofylline (1.5 mg/kg/min) produced an overall increase in local cerebral blood flow and a marked reduction in glucose utilization. Furthermore, propentofylline increased the average ratio of blood flow per unit glucose utilization and thus is capable of increasing cerebral blood flow in excess of metabolic demand. While the mechanism of action of this compound has not been fully defined, it is possible that its cerebrovascular and cerebral metabolic effects can at least partially be explained by a blockade of adenosine uptake. These actions of propentofylline on cerebral blood flow and metabolism may play a role in protecting neuronal tissue under hypoxic/ischemic conditions in the brain.
采用定量放射自显影技术测定了黄嘌呤衍生物丙戊茶碱[3-甲基-1-(5'-氧代己基)-7-丙基黄嘌呤]对大鼠局部脑血流量和葡萄糖利用的影响。静脉注射剂量为0.5mg/kg/min时，在所测量的大多数脑结构中，局部脑血流量增加，而对葡萄糖利用的影响最小。更高剂量的丙戊茶碱（1.5mg/kg/min）使局部脑血流量总体增加，葡萄糖利用显著降低。此外，丙戊茶碱增加了单位葡萄糖利用的血流平均比值，因此能够使脑血流量增加超过代谢需求。虽然该化合物的作用机制尚未完全明确，但有可能其脑血管和脑代谢作用至少部分可通过腺苷摄取的阻断来解释。丙戊茶碱对脑血流量和代谢的这些作用可能在保护脑内缺氧/缺血条件下的神经元组织中发挥作用。
