el Fawal M A, Berg G A, Wheatley D J, Harland W A
Br Heart J. 1987 Apr;57(4):329-35. doi: 10.1136/hrt.57.4.329.
A detailed pathological study of the coronary arteries was carried out on 130 random white subjects (91 male and 39 female) who died suddenly in the Glasgow area. In 30 there was a clearly defined cause of death that was not due to ischaemic heart disease. In eight subjects the cause of death was in doubt. Ninety two of the 130 showed coronary stenosis resulting in a loss of more than 75% of coronary artery cross sectional area and/or acute coronary events with no other cause of death. Of these 92 subjects considered to have died suddenly of ischaemic heart disease, 64% showed plaque rupture and thrombosis which occurred at sites of previous high grades of stenosis. Twenty two subjects had intraluminal thrombosis unrelated to plaque fissuring. Thirty eight (41%) showed histological evidence of recent myocardial necrosis; acute coronary events occurred in 34 of these. There was no correlation between the duration of symptoms before death and the occurrence of acute coronary events. Acute coronary events, mainly in the form of plaque rupture, are a common finding in sudden coronary death when a careful study is made of the whole coronary arterial tree.
对格拉斯哥地区130名随机选取的白人受试者（91名男性和39名女性）进行了冠状动脉的详细病理研究，这些受试者均为突然死亡。其中30人有明确的死因，并非缺血性心脏病所致。8名受试者的死因存疑。130名受试者中有92人出现冠状动脉狭窄，导致冠状动脉横截面积损失超过75%，和/或发生急性冠状动脉事件，且无其他死因。在这92名被认为死于缺血性心脏病猝死的受试者中，64%表现为斑块破裂和血栓形成，且发生在先前高度狭窄的部位。22名受试者有与斑块破裂无关的管腔内血栓形成。38名（41%）有近期心肌坏死的组织学证据；其中34人发生了急性冠状动脉事件。死亡前症状持续时间与急性冠状动脉事件的发生之间无相关性。当对整个冠状动脉树进行仔细研究时，急性冠状动脉事件，主要表现为斑块破裂，是冠状动脉猝死的常见表现。
