心脏直视手术后的咪达唑仑镇静

Midazolam sedation following open heart surgery.

作者信息

Mathews H M, Carson I W, Collier P S, Dundee J W, Fitzpatrick K, Howard P J, Lyons S M, Orr I A

出版信息

Br J Anaesth. 1987 May;59(5):557-60. doi: 10.1093/bja/59.5.557.

DOI:10.1093/bja/59.5.557

Abstract

Midazolam given as hourly intermittent injections was compared with the same dose given by infusion for postoperative sedation in patients after cardiopulmonary bypass. A stable concentration was rapidly attained with the infusion whereas 6-8 h was required to attain stable plasma (trough) concentrations in the intermittent injection group. Plasma concentrations decreased rapidly to low values within 6 h of discontinuation of therapy. High plasma concentrations and a long (16 h) half-life were noted in one patient who may be a slow metabolizer of the drug.

摘要

在接受心肺转流术的患者中，比较了每小时间歇性注射咪达唑仑与静脉输注相同剂量咪达唑仑用于术后镇静的效果。静脉输注能迅速达到稳定浓度，而间歇性注射组则需要6 - 8小时才能达到稳定的血浆（谷值）浓度。停药后6小时内，血浆浓度迅速降至低值。在一名患者中观察到高血浆浓度和长（16小时）半衰期，该患者可能是该药物的慢代谢者。