Clinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia.
Department of Pathological Physiology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia.
Pregnancy Hypertens. 2022 Aug;29:72-85. doi: 10.1016/j.preghy.2022.06.007. Epub 2022 Jul 2.
Hypertensive disorders in pregnancy represent severe complications of pregnancy, which, if not treated, can result in serious health consequences for the mother and the child. Flavonoids are bioactive secondary metabolites commonly found in fruits, vegetables, green tea, whole grains, and medicinal plants. Flavonoids exert potent protective efficacy in experimental models of hypertensive disorders in pregnancy, especially preeclampsia, demonstrated through their capacity to modulate inflammatory responses, oxidative stress, and vascular dysfunction. In addition to their potential as therapeutics, flavonoids or flavonoid-rich food could be helpful to decrease the risk of hypertensive disorders in pregnancy when included in the diet pattern before and during pregnancy. However, the clinical evaluation of the potential capacity of flavonoids in hypertensive disorders in pregnancy is insufficient. Due to promising results from experimental studies, we highlight the need for the evaluation of flavonoids also in an appropriate clinical setting, which can be, together with proper preventive strategies, helpful in the overall management of hypertensive disorders in pregnancy.
妊娠高血压疾病是妊娠的严重并发症，如果不治疗，可能会对母亲和孩子的健康造成严重后果。类黄酮是一种常见于水果、蔬菜、绿茶、全谷物和药用植物中的生物活性次生代谢物。类黄酮在妊娠高血压疾病的实验模型中具有强大的保护作用，特别是子痫前期，这是通过其调节炎症反应、氧化应激和血管功能障碍的能力来证明的。除了作为治疗剂的潜力外，类黄酮或富含类黄酮的食物如果在妊娠前和妊娠期间纳入饮食模式，可能有助于降低妊娠高血压疾病的风险。然而，类黄酮在妊娠高血压疾病中的潜在作用的临床评估还不够。由于实验研究的结果很有希望，我们强调需要在适当的临床环境中评估类黄酮，这可以与适当的预防策略一起，有助于妊娠高血压疾病的整体管理。
