Department of Mechanical Science and Engineering, Hirosaki University, Hirosaki, Aomori, 036-8561, Japan.
Department of Mechanical Science and Engineering, Hirosaki University, Hirosaki, Aomori, 036-8561, Japan.
J Mech Behav Biomed Mater. 2022 Sep;133:105330. doi: 10.1016/j.jmbbm.2022.105330. Epub 2022 Jun 25.
Hydroxyapatite (HAp) is a biomaterial used because of its high potential for improving the healing of bone fractures. HAp is typically prepared using synthetic methods. However, synthetic HAp generally does not contain trace elements, which are considered to be important factors in the healing process. Therefore, researchers have focused on developing methods for preparing biomaterials containing trace elements. A novel method for coating calcium phosphate materials with trace elements is proposed in this study. In this method, mineral components with trace elements were obtained from bone samples and coated onto the titanium surface using only electrical stimulation under constant voltage application in phosphate-buffered saline. The resulting material had poor crystallinity, which was similar to apatite structure present in bone tissue, and it contained trace elements. Calcium phosphate depositions were also constructed on the surfaces of bone and vascular specimens under the same conditions. Consequently, this method can potentially be applied as an innovative treatment for implant surfaces and in the preparation of scaffolds for bone tissue engineering.
羟基磷灰石（HAp）是一种生物材料，因其具有促进骨折愈合的巨大潜力而被广泛应用。HAp 通常采用合成方法制备。然而，合成 HAp 通常不含有微量元素，而微量元素被认为是愈合过程中的重要因素。因此，研究人员一直致力于开发含有微量元素的生物材料制备方法。本研究提出了一种在钙磷材料上涂覆微量元素的新方法。在该方法中，从骨样本中获得含微量元素的矿物成分，并仅在磷酸盐缓冲盐溶液中施加恒定电压的电刺激下将其涂覆到钛表面上。所得材料结晶度较差，类似于骨组织中存在的磷灰石结构，并且含有微量元素。在相同条件下，在骨和血管标本的表面也构建了钙磷沉积物。因此，该方法有望作为植入物表面的创新治疗方法，并可用于制备骨组织工程支架。
