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含锶生物材料在骨组织工程中的高级应用。

Advanced applications of strontium-containing biomaterials in bone tissue engineering.

作者信息

Sheng Xiao, Li Chen, Wang Zhonghan, Xu Yu, Sun Yang, Zhang Weimin, Liu He, Wang Jincheng

机构信息

Department of Orthopedics, The Second Hospital of Jilin University, Changchun, 130041, Jilin, China.

出版信息

Mater Today Bio. 2023 Apr 15;20:100636. doi: 10.1016/j.mtbio.2023.100636. eCollection 2023 Jun.

DOI:10.1016/j.mtbio.2023.100636
PMID:37441138
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10333686/
Abstract

Strontium (Sr) and strontium ranelate (SR) are commonly used therapeutic drugs for patients suffering from osteoporosis. Researches have showed that Sr can significantly improve the biological activity and physicochemical properties of materials and . Therefore, a large number of strontium containing biomaterials have been developed for repairing bone defects and promoting osseointegration. In this review, we provide a comprehensive overview of Sr-containing biomaterials along with the current state of their clinical use. For this purpose, the different types of biomaterials including calcium phosphate, bioactive glass, and polymers are discussed and provided future outlook on the fabrication of the next-generation multifunctional and smart biomaterials.

摘要

锶（Sr）和雷奈酸锶（SR）是常用于骨质疏松症患者的治疗药物。研究表明，Sr可以显著改善材料的生物活性和物理化学性质。因此，人们开发了大量含锶生物材料用于修复骨缺损和促进骨整合。在这篇综述中，我们全面概述了含Sr生物材料及其临床应用现状。为此，讨论了包括磷酸钙、生物活性玻璃和聚合物在内的不同类型生物材料，并对下一代多功能智能生物材料的制造提供了未来展望。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da13/10333686/07353b4b81c0/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da13/10333686/04d27573d936/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da13/10333686/ff96911f1c83/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da13/10333686/3a217445275f/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da13/10333686/d7303dbd5113/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da13/10333686/8b410ecd6539/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da13/10333686/1726634ffc2a/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da13/10333686/938bba39da38/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da13/10333686/fb59b7f03775/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da13/10333686/3ff701b06a58/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da13/10333686/07353b4b81c0/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da13/10333686/04d27573d936/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da13/10333686/ff96911f1c83/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da13/10333686/3a217445275f/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da13/10333686/d7303dbd5113/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da13/10333686/8b410ecd6539/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da13/10333686/1726634ffc2a/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da13/10333686/938bba39da38/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da13/10333686/fb59b7f03775/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da13/10333686/3ff701b06a58/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da13/10333686/07353b4b81c0/gr9.jpg

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