Naveh N, Zborowsky-Gutman L, Blumenthal M
Br J Ophthalmol. 1987 Apr;71(4):257-61. doi: 10.1136/bjo.71.4.257.
A prospective short-term preliminary clinical study to evaluate the efficacy and immediate complications of Q-switched Nd-YAG laser iridotomy in the treatment of acute and chronic angle closure glaucoma is described. The follow-up period ranged from four to 10 months. Of 40 eyes treated 36 (90%) required a single lasing session for patency (19, one application; 17, two applications), and four eyes (10%) required two sessions. Closure of the iridotomy site following Nd-YAG lasing due to pigment epithelium proliferation occurred in 10% of eyes, an incidence remarkably lower than that of argon laser iridotomy. Transitory closure or diminution of a prior patent iridotomy during the first hour after lasing was observed in 6.7% of eyes. Patency was again noted up to three weeks later and remained unchanged. Immediate postoperative complications included a marked increase in ocular pressure (42% of eyes), minimal transitory bleeding, and transitory localised corneal oedema at the lasing site. Persistent iridocorneal adhesion at the lasing site was noted in three eyes, and localised lenticular opacities, of non-progressive type, were observed in one eye.
本文描述了一项前瞻性短期初步临床研究，旨在评估调Q开关Nd:YAG激光虹膜切开术治疗急性和慢性闭角型青光眼的疗效及即时并发症。随访期为4至10个月。在接受治疗的40只眼中，36只眼（90%）单次激光治疗即可实现虹膜切开术通畅（19只眼一次治疗；17只眼两次治疗），4只眼（10%）需要两次治疗。10%的眼因色素上皮增生导致Nd:YAG激光治疗后虹膜切开部位闭合，这一发生率显著低于氩激光虹膜切开术。6.7%的眼在激光治疗后第一小时内出现先前通畅的虹膜切开术短暂闭合或缩小。三周后再次观察到通畅且保持不变。术后即时并发症包括眼压显著升高（42%的眼）、少量短暂出血以及激光治疗部位短暂局限性角膜水肿。三只眼在激光治疗部位出现持续性虹膜角膜粘连，一只眼观察到非进行性局限性晶状体混浊。
