Martínez-Montoro José Ignacio, Martínez-Sánchez María Antonia, Balaguer-Román Andrés, Gil-Martínez José, Mesa-López María José, Egea-Valenzuela Juan, Ruiz-Alcaraz Antonio José, Queipo-Ortuño María Isabel, Ferrer Mercedes, Fernández-García José Carlos, Ramos-Molina Bruno
Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Instituto de Investigacion Biomedica de Malaga (IBIMA), Faculty of Medicine, University of Malaga, Malaga, Spain.
Obesity and Metabolism Laboratory, Biomedical Research Institute of Murcia (IMIB), Murcia, Spain.
Int J Surg. 2022 Aug;104:106751. doi: 10.1016/j.ijsu.2022.106751. Epub 2022 Jul 5.
Colorectal cancer (CRC) is the third most frequent malignancy and the second cause of cancer death worldwide. Several factors have been postulated to be involved in CRC pathophysiology, including physical inactivity, unhealthy dietary habits, obesity, and the gut microbiota. Emerging data suggest that the microbiome may play a key role in CRC prognosis and derived complications in patients undergoing colorectal surgery. On the other hand, dietary intervention has been demonstrated to be able to induce significant changes in the gut microbiota and related metabolites in different conditions; therefore, the manipulation of gut microbiota through dietary intervention may constitute a useful approach to improve perioperative dysbiosis and post-surgical outcomes in patients with CRC. In this article, we review the role of the gut microbiota in CRC surgery complications and the potential therapeutic modulation of gut microbiome through nutritional intervention in patients with CRC undergoing surgery.
结直肠癌（CRC）是全球第三常见的恶性肿瘤，也是癌症死亡的第二大原因。据推测，多种因素参与了结直肠癌的病理生理过程，包括缺乏运动、不健康的饮食习惯、肥胖和肠道微生物群。新出现的数据表明，微生物群可能在接受结直肠手术患者的结直肠癌预后及相关并发症中起关键作用。另一方面，饮食干预已被证明能够在不同情况下引起肠道微生物群及相关代谢产物的显著变化；因此，通过饮食干预来调节肠道微生物群可能是改善结直肠癌患者围手术期生态失调和术后结局的一种有效方法。在本文中，我们综述了肠道微生物群在结直肠癌手术并发症中的作用，以及通过营养干预对接受手术的结直肠癌患者肠道微生物群进行潜在治疗性调节的相关内容。
