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Peroxisome proliferator-activated receptor gamma (PPAR-γ) activation through gut microbiota modulation as a novel therapeutic approach against anastomotic leak after colorectal cancer surgery.

作者信息

Núñez-Sánchez María Ángeles, Martínez-Sánchez María Antonia, Ramos-Molina Bruno

机构信息

Obesity, Diabetes and Metabolism Laboratory, Biomedical Research Institute of Murcia (IMIB), Murcia, Spain.

出版信息

J Gastrointest Oncol. 2024 Oct 31;15(5):2338-2342. doi: 10.21037/jgo-24-314. Epub 2024 Oct 14.

DOI:10.21037/jgo-24-314
PMID:39554579
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11565100/
Abstract
摘要

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Peroxisome proliferator-activated receptor gamma (PPAR-γ) activation through gut microbiota modulation as a novel therapeutic approach against anastomotic leak after colorectal cancer surgery.通过调节肠道微生物群激活过氧化物酶体增殖物激活受体γ（PPAR-γ）作为结直肠癌手术后吻合口漏的一种新型治疗方法。
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2
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Ameliorates Colorectal Cancer by Ameliorating the Intestinal Barrier through the CLA-PPAR-γ Axis.通过 CLA-PPAR-γ 轴改善肠道屏障来缓解结直肠癌。
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本文引用的文献

1
PPARG activation promotes the proliferation of colorectal cancer cell lines and enhances the antiproliferative effect of 5-fluorouracil.过氧化物酶体增殖物激活受体 γ 的激活促进结直肠癌细胞系的增殖，并增强氟尿嘧啶的抗增殖作用。
BMC Cancer. 2024 Feb 20;24(1):234. doi: 10.1186/s12885-024-11985-5.
2
Modulating Gut Microbiota Prevents Anastomotic Leak to Reduce Local Implantation and Dissemination of Colorectal Cancer Cells after Surgery.调节肠道微生物群可预防吻合口漏，减少结直肠癌手术后局部种植和播散。
Clin Cancer Res. 2024 Feb 1;30(3):616-628. doi: 10.1158/1078-0432.CCR-23-1601.
3
Deciphering the interaction between Twist1 and PPARγ during adipocyte differentiation.
解析 Twist1 和 PPARγ 在脂肪细胞分化过程中的相互作用。
Cell Death Dis. 2023 Nov 23;14(11):764. doi: 10.1038/s41419-023-06283-0.
4
Crosstalk between gut microbiota and metastasis in colorectal cancer: implication of neutrophil extracellular traps.结直肠癌中肠道微生物群与转移的串扰：中性粒细胞胞外陷阱的作用。
Front Immunol. 2023 Oct 23;14:1296783. doi: 10.3389/fimmu.2023.1296783. eCollection 2023.
5
The impact of anastomotic leakage after curative colon cancer resection on long-term survival: A retrospective cohort study.根治性结肠癌切除术后吻合口漏对长期生存的影响：一项回顾性队列研究。
Cir Esp (Engl Ed). 2024 Jan;102(1):3-10. doi: 10.1016/j.cireng.2023.05.011. Epub 2023 Jul 7.
6
Basal levels of microbiota-driven subclinical inflammation are associated with anastomotic leak in patients with colorectal cancer.微生物群驱动的亚临床炎症的基础水平与结直肠癌患者的吻合口漏相关。
Gut. 2024 May 10;73(6):1031-1033. doi: 10.1136/gutjnl-2023-329929.
7
Predictive Factors for Anastomotic Leakage Following Colorectal Cancer Surgery: Where Are We and Where Are We Going?结直肠癌手术后吻合口漏的预测因素：我们在哪里，我们要去哪里？
Curr Oncol. 2023 Mar 7;30(3):3111-3137. doi: 10.3390/curroncol30030236.
8
Intestinal bacteria and colorectal cancer: etiology and treatment.肠道细菌与结直肠癌：病因与治疗。
Gut Microbes. 2023 Jan-Dec;15(1):2185028. doi: 10.1080/19490976.2023.2185028.
9
Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN.2020年和2040年全球结直肠癌负担：来自全球癌症负担（GLOBOCAN）的发病率和死亡率估计
Gut. 2023 Feb;72(2):338-344. doi: 10.1136/gutjnl-2022-327736. Epub 2022 Sep 8.
10
Gut microbiota influence anastomotic healing in colorectal cancer surgery through modulation of mucosal proinflammatory cytokines.肠道微生物通过调节粘膜促炎细胞因子影响结直肠癌手术吻合口愈合。
Gut. 2023 Jun;72(6):1143-1154. doi: 10.1136/gutjnl-2022-328389. Epub 2022 Dec 30.