新型高亲和力 SARS-CoV-2 刺突蛋白 S2 结合肽的 PhIP-Seq 筛选发现。
New discovery of high-affinity SARS-CoV-2 spike S2 protein binding peptide selected by PhIP-Seq.
机构信息
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, South Xiang'an Road, Xiamen, 361102, China.
Xiamen Haicang Hospital, Haiyu Road, Xiamen, 361026, China.
出版信息
Virol Sin. 2022 Oct;37(5):758-761. doi: 10.1016/j.virs.2022.07.001. Epub 2022 Jul 5.
• A peptide Spep-1 targeting S2 of SARS-CoV-2 spike protein was selected by PhIP-Seq. • Spep-1 showed nanomolar affinity and high specificity to spike protein. • S-1 based immunoassay can detect femtomolar spike antigen in spiked serum samples. • Spep-1 can be used in future on S2 recognition, virus tracing and drug delivery.
• 通过 PhIP-Seq 筛选出靶向 SARS-CoV-2 刺突蛋白 S2 的肽 Spep-1。• Spep-1 对刺突蛋白表现出纳摩尔亲和力和高度特异性。• 基于 S-1 的免疫测定法可检测到加标血清样本中的皮摩尔级刺突抗原。• Spep-1 可用于未来的 S2 识别、病毒追踪和药物递送。
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