• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Genetic identification of rat liver carboxylesterases isolated in different laboratories.

作者信息

Mentlein R, Ronai A, Robbi M, Heymann E, von Deimling O

出版信息

Biochim Biophys Acta. 1987 May 27;913(1):27-38. doi: 10.1016/0167-4838(87)90228-7.

DOI:10.1016/0167-4838(87)90228-7
PMID:3580374
Abstract

Six carboxylesterases previously isolated from rat liver microsomes, characterized in Brussels and in Kiel, were compared with genetically defined liver esterases of various reference strains using polyacrylamide gel electrophoresis and isoelectric focusing. The six liver carboxylesterases were identified as alloenzymic forms of ES-3, ES-4, ES-8/ES-10 and ES-15 according to the genetic nomenclature recommended by van Zutphen (Van Zutphen, L.F.M. (1983) Transplant. Proceed. 15, 1687-1688). The genetic and biochemical characteristics of the four isoenzymes are summarized, and their identity with several other drug-metabolizing esterases/amidases and lipases of rat liver endoplasmic reticulum is discussed.

摘要

相似文献

1
Genetic identification of rat liver carboxylesterases isolated in different laboratories.
Biochim Biophys Acta. 1987 May 27;913(1):27-38. doi: 10.1016/0167-4838(87)90228-7.
2
Carboxylesterases-amidases.羧酸酯酶-酰胺酶
Methods Enzymol. 1981;77:333-44. doi: 10.1016/s0076-6879(81)77047-2.
3
Identification and development of a genetically closely-linked carboxylesterase family of the mouse liver.
Comp Biochem Physiol B. 1985;80(4):859-65. doi: 10.1016/0305-0491(85)90475-4.
4
Heterogeneity of carboxylesterases in rat liver cells.
Biochem Pharmacol. 1992 Aug 18;44(4):827-9. doi: 10.1016/0006-2952(92)90423-g.
5
Purification and characterization of carboxylesterases from rat lung.大鼠肺羧酸酯酶的纯化与鉴定
Biochem J. 1991 Mar 15;274 ( Pt 3)(Pt 3):693-7. doi: 10.1042/bj2740693.
6
Purification and molecular properties of rabbit liver esterase ES-1A.兔肝酯酶ES-1A的纯化及分子特性
Eur J Biochem. 1989 Oct 1;184(3):545-51. doi: 10.1111/j.1432-1033.1989.tb15048.x.
7
Identity of purified monoacylglycerol lipase, palmitoyl-CoA hydrolase and aspirin-metabolizing carboxylesterase from rat liver microsomal fractions. A comparative study with enzymes purified in different laboratories.大鼠肝微粒体组分中纯化的单酰甘油脂肪酶、棕榈酰辅酶A水解酶和阿司匹林代谢羧酸酯酶的鉴定。与不同实验室纯化的酶的比较研究。
Biochem J. 1985 Dec 1;232(2):479-83. doi: 10.1042/bj2320479.
8
Hydrolysis of retinyl esters by non-specific carboxylesterases from rat liver endoplasmic reticulum.大鼠肝脏内质网非特异性羧酸酯酶对视黄酯的水解作用。
Biochem J. 1987 Aug 1;245(3):863-7. doi: 10.1042/bj2450863.
9
Specificity of the sex-influenced esterase (ES-SI) isozyme in rat liver.
Biochem Genet. 1991 Jun;29(5-6):261-9. doi: 10.1007/BF00590106.
10
Genetic identification of non-specific esterases of the mouse cauda epididymidis and description of esterase-28, a new carboxylesterase isoenzyme (EC 3.1.1.1).小鼠附睾尾非特异性酯酶的基因鉴定及一种新的羧酸酯酶同工酶（EC 3.1.1.1）酯酶-28的描述。
J Reprod Fertil. 1990 Jan;88(1):41-50. doi: 10.1530/jrf.0.0880041.

引用本文的文献

1
Rat carboxylesterase ES-4 enzyme functions as a major hepatic neutral cholesteryl ester hydrolase.大鼠羧酸酯酶 ES-4 酶作为主要的肝中性胆固醇酯水解酶发挥作用。
J Biol Chem. 2011 Nov 18;286(46):39683-92. doi: 10.1074/jbc.M111.258095. Epub 2011 Sep 20.
2
Vitamin A metabolism: an update.维生素 A 代谢：更新。
Nutrients. 2011 Jan;3(1):63-103. doi: 10.3390/nu3010063.
3
Sialic acid 9-O-acetylesterase catalyzes the hydrolyzing reaction from alacepril to deacetylalacepril.唾液酸9-O-乙酰酯酶催化阿替洛尔向去乙酰阿替洛尔的水解反应。
Pharm Res. 2003 Aug;20(8):1309-16. doi: 10.1023/a:1025073720126.
4
Comparative metabolism of chloroacetamide herbicides and selected metabolites in human and rat liver microsomes.氯乙酰胺类除草剂及其选定代谢物在人和大鼠肝微粒体中的比较代谢。
Environ Health Perspect. 2000 Dec;108(12):1151-7. doi: 10.1289/ehp.001081151.
5
Cloning and sequencing of rat liver carboxylesterase ES-4 (microsomal palmitoyl-CoA hydrolase).大鼠肝脏羧酸酯酶ES-4（微粒体棕榈酰辅酶A水解酶）的克隆与测序
Biochem J. 1996 Feb 1;313 ( Pt 3)(Pt 3):821-6. doi: 10.1042/bj3130821.
6
Purification, characterization and modulation of a microsomal carboxylesterase in rat liver for the hydrolysis of acyl-CoA.大鼠肝脏中一种用于水解酰基辅酶A的微粒体羧酸酯酶的纯化、特性鉴定及调节
Biochem J. 1993 Oct 1;295 ( Pt 1)(Pt 1):81-6. doi: 10.1042/bj2950081.
7
Biosynthesis of rat liver pI-6.1 esterase, a carboxylesterase of the cisternal space of the endoplasmic reticulum.大鼠肝脏pI-6.1酯酶的生物合成，一种内质网池腔的羧酸酯酶。
Biochem J. 1987 Dec 1;248(2):545-50. doi: 10.1042/bj2480545.
8
Esterase-16 (ES-16) of the rat (Rattus norvegicus): identification and genetic characterization.大鼠（褐家鼠）的酯酶-16（ES-16）：鉴定与遗传特征分析。
Biochem Genet. 1988 Oct;26(9-10):605-15. doi: 10.1007/BF02399605.
9
Immunochemical characterization and biosynthesis of pI-6.4 esterase, a carboxylesterase of rat liver microsomal extracts.大鼠肝微粒体提取物中的一种羧酸酯酶——pI-6.4酯酶的免疫化学特性及生物合成
Biochem J. 1988 Aug 15;254(1):51-7. doi: 10.1042/bj2540051.
10
Nucleotide sequence of cDNA coding for rat liver pI 6.1 esterase (ES-10), a carboxylesterase located in the lumen of the endoplasmic reticulum.编码大鼠肝脏pI 6.1酯酶（ES-10）的cDNA核苷酸序列，ES-10是一种位于内质网腔中的羧酸酯酶。
Biochem J. 1990 Jul 15;269(2):451-8. doi: 10.1042/bj2690451.