大鼠（褐家鼠）的酯酶-16（ES-16）：鉴定与遗传特征分析。

Esterase-16 (ES-16) of the rat (Rattus norvegicus): identification and genetic characterization.

作者信息

von Deimling O H, Simon B, Kluge R, Hedrich H

机构信息

Pathologisches Institut Universität Freiburg, F.R.G.

出版信息

Biochem Genet. 1988 Oct;26(9-10):605-15. doi: 10.1007/BF02399605.

DOI:10.1007/BF02399605

PMID:3242497

Abstract

Esterase-16, an esterase present in lung and other tissues of the laboratory rat, has been characterized by its biochemical properties (electrophoretic mobility, substrate pattern, sensitivity to inhibitors) and genetic variation in 107 inbred strains and substrains including 14 RI strains. It was classified as a carboxylesterase (EC 3.1.1.1). The phenotype ES-16A (BN/Han and 63 other strains) was defined as a narrow electrophoretic band migrating between ES-1A and ES-13A, ES-16B (LEW/Han and 42 other strains) exhibited the same electrophoretic mobility as ES-16A but was distinguished by its extremely weak activity. Segregation of ES-16 in RI strains and backcrosses indicated linkage to linkage group V (LGV). The Es-16 locus was tentatively placed into esterase cluster 2 and homology with Es-7 of the house mouse is proposed.

摘要

酯酶-16是一种存在于实验大鼠肺及其他组织中的酯酶，已通过其生化特性（电泳迁移率、底物模式、对抑制剂的敏感性）以及在包括14个重组近交系在内的107个近交系和亚系中的遗传变异进行了表征。它被归类为羧酸酯酶（EC 3.1.1.1）。ES-16A表型（BN/Han及其他63个品系）被定义为在ES-1A和ES-13A之间迁移的窄电泳带，ES-16B（LEW/Han及其他42个品系）表现出与ES-16A相同的电泳迁移率，但以其极低的活性而有别于ES-16A。酯酶-16在重组近交系和回交中的分离表明它与第五连锁群（LGV）连锁。Es-16基因座被初步定位到酯酶簇2，并推测与家鼠的Es-7具有同源性。