Reyes J L, Roch-Ramel F, Besseghir K
Biol Neonate. 1987;51(4):212-6. doi: 10.1159/000242654.
In contrast to adult tubules, a bath-to-lumen sodium gradient was followed by net sodium entry in the lumen of in vitro isolated perfused newborn (3-5 days) rabbit collecting tubules. In addition, transepithelial voltage and electrical resistance were lower in newborn tubules. The sodium flux into the lumen was unaffected by indomethacin. These observations suggest that the newborn collecting tubule may be unable to maintain an adequate sodium gradient for the optimal function of the urinary concentrating mechanism, and that endogenous prostaglandins are not involved in this defect.
与成年肾小管不同，在体外分离灌注的新生（3 - 5天）兔集合小管管腔中，从浴液到管腔的钠梯度之后伴随着钠的净进入。此外，新生小管的跨上皮电压和电阻较低。进入管腔的钠通量不受吲哚美辛的影响。这些观察结果表明，新生集合小管可能无法维持足够的钠梯度以实现尿液浓缩机制的最佳功能，并且内源性前列腺素不参与这一缺陷。
