Wang Hongyu, Zhang He, Su Yong
Laboratory of Gastrointestinal Microbiology, Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
National Center for International Research on Animal Gut Nutrition, Nanjing Agricultural University, Nanjing 210095, China.
Animals (Basel). 2022 Jun 29;12(13):1677. doi: 10.3390/ani12131677.
Unlike the strictly hierarchical organization in the circadian clock system, the gut microbiota rhythmicity has a more complex multilayer network of all taxonomic levels of microbial taxa and their metabolites. However, it is worth noting that the functionality of the gut microbiota rhythmicity is highly dependent on the host circadian clock and host physiological status. Here, we discussed the diurnal rhythmicity of the gut microbiota; its crucial role in host physiology, health, and metabolism; and the crosstalk between the gut microbial rhythmicity and host circadian rhythm. This knowledge lays the foundation for the development of chronotherapies targeting the gut microbiota. However, the formation mechanism, its beneficial effects on the host of gut microbial rhythmicity, and the dynamic microbial-host crosstalk are not yet clear and warrant further research.
与昼夜节律时钟系统中严格的层级组织不同，肠道微生物群的节律性具有更复杂的多层网络，涵盖了微生物分类群及其代谢产物的所有分类水平。然而，值得注意的是，肠道微生物群节律性的功能高度依赖于宿主昼夜节律时钟和宿主生理状态。在此，我们讨论了肠道微生物群的昼夜节律性；其在宿主生理、健康和代谢中的关键作用；以及肠道微生物节律性与宿主昼夜节律之间的相互作用。这些知识为开发针对肠道微生物群的时辰疗法奠定了基础。然而，肠道微生物节律性的形成机制、其对宿主的有益作用以及微生物与宿主之间的动态相互作用尚不清楚，值得进一步研究。
