RNA中的甲基腺苷修饰：从调控作用到在癌症中的治疗意义
Methyladenosine Modification in RNAs: From Regulatory Roles to Therapeutic Implications in Cancer.
作者信息
Qu Xiaolin, Zhang Yongqiu, Sang Xianzheng, Ren Ding, Zhao Hong, Wong Stephen T C
机构信息
Department of Neurosurgery, Changzheng Hospital, Naval Medical University, Shanghai 200003, China.
Department of Radiology, PLA No. 905 Hospital, Naval Medical University, Shanghai 200050, China.
出版信息
Cancers (Basel). 2022 Jun 29;14(13):3195. doi: 10.3390/cancers14133195.
Methyladenosine modifications are the most abundant RNA modifications, including N6-methyladenosine (mA), N1-methyladenosine (mA), and 2'-O-methyladenosine (mA). As reversible epigenetic modifications, methyladenosine modifications in eukaryotic RNAs are not invariable. Drastic alterations of mA are found in a variety of diseases, including cancers. Dynamic changes of mA modification induced by abnormal methyltransferase, demethylases, and readers can regulate cancer progression via interfering with the splicing, localization, translation, and stability of mRNAs. Meanwhile, mA, mA, and mA modifications also exert regulatory effects on noncoding RNAs in cancer progression. In this paper, we reviewed recent findings concerning the underlying biomechanism of methyladenosine modifications in oncogenesis and metastasis and discussed the therapeutic potential of methyladenosine modifications in cancer treatments.
甲基腺苷修饰是最为丰富的RNA修饰类型，包括N6-甲基腺苷（m6A）、N1-甲基腺苷（m1A）和2'-O-甲基腺苷（mAm）。作为可逆的表观遗传修饰，真核生物RNA中的甲基腺苷修饰并非一成不变。在包括癌症在内的多种疾病中都发现了m6A的显著改变。由异常的甲基转移酶、去甲基酶和阅读蛋白诱导的m6A修饰动态变化，可通过干扰mRNA的剪接、定位、翻译和稳定性来调节癌症进展。同时，m6A、m1A和mAm修饰在癌症进展过程中对非编码RNA也发挥着调控作用。在本文中，我们综述了有关甲基腺苷修饰在肿瘤发生和转移中的潜在生物机制的最新研究结果，并讨论了甲基腺苷修饰在癌症治疗中的治疗潜力。
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