Zhang Runjiao, Zhang Yizhou, Guo Fangzhen, Li Sha, Cui Huixian
Department of Anatomy, Hebei Medical University, Shijiazhuang, China.
Neuroscience Research Center, Hebei Medical University, Shijiazhuang, China.
Front Cell Neurosci. 2022 Mar 24;16:820378. doi: 10.3389/fncel.2022.820378. eCollection 2022.
The importance of epitranscriptomics in regulating gene expression has received widespread attention. Recently, RNA methylation modifications, particularly N6-methyladenosine (mA), have received marked attention. mA, the most common and abundant type of eukaryotic methylation modification in RNAs, is a dynamic reversible modification that regulates nuclear splicing, stability, translation, and subcellular localization of RNAs. These processes are involved in the occurrence and development of many diseases. An increasing number of studies have focused on the role of mA modification in Alzheimer's disease, which is the most common neurodegenerative disease. This review focuses on the general features, mechanisms, and functions of mA methylation modification and its role in Alzheimer's disease.
表观转录组学在调控基因表达中的重要性已受到广泛关注。最近，RNA甲基化修饰，尤其是N6-甲基腺苷（m6A），受到了显著关注。m6A是RNA中最常见且含量丰富的真核甲基化修饰类型，是一种动态可逆修饰，可调节RNA的核剪接、稳定性、翻译及亚细胞定位。这些过程与许多疾病的发生和发展有关。越来越多的研究聚焦于m6A修饰在阿尔茨海默病（最常见的神经退行性疾病）中的作用。本综述重点关注m6A甲基化修饰的一般特征、机制和功能及其在阿尔茨海默病中的作用。
