Reiser Elisabeth, Pils Dietmar, Grimm Christoph, Hoffmann Ines, Polterauer Stephan, Kranawetter Marlene, Aust Stefanie
Department of Gynecological Endocrinology and Reproductive Medicine, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Division of Visceral Surgery, Department of General Surgery, Comprehensive Cancer Center (CCC), Medical University of Vienna, 1090 Vienna, Austria.
Cancers (Basel). 2022 Jun 30;14(13):3210. doi: 10.3390/cancers14133210.
Discrimination between benign and malignant adnexal masses is essential for optimal treatment planning, but still remains challenging in a routine clinical setting. In this retrospective study, we aimed to compare albumin as a single parameter to calculate models by analyzing laboratory parameters of 1552 patients with an adnexal mass (epithelial ovarian cancer (EOC): = 294; borderline tumor of the ovary (BTO): = 66; benign adnexal mass: = 1192) undergoing surgery. Models comprising classical laboratory parameters show better accuracies (AUCs 0.92-0.93; 95% CI 0.90-0.95) compared to the use of single markers, and could easily be implemented in clinical practice by containing only readily available markers. This has been incorporated into a nomogram.
鉴别附件包块的良恶性对于制定最佳治疗方案至关重要，但在常规临床环境中仍然具有挑战性。在这项回顾性研究中，我们旨在通过分析1552例接受手术的附件包块患者（上皮性卵巢癌（EOC）：= 294例；卵巢交界性肿瘤（BTO）：= 66例；良性附件包块：= 1192例）的实验室参数，比较将白蛋白作为单一参数来计算模型的情况。与使用单一标志物相比，包含经典实验室参数的模型显示出更高的准确性（AUC为0.92 - 0.93；95%CI为0.90 - 0.95），并且由于只包含易于获得的标志物，因此可以很容易地应用于临床实践。这已被纳入一个列线图中。
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