Allemann-Su Yu-Yin, Vetter Marcus, Koechlin Helen, Paul Steven M, Cooper Bruce A, Oppegaard Kate, Melisko Michelle, Levine Jon D, Conley Yvette, Miaskowski Christine, Katapodi Maria C
Department of Clinical Research, University of Basel, 4055 Basel, Switzerland.
Department of Oncology, Cantonal Hospital Basel-Land, 4410 Listel, Switzerland.
Cancers (Basel). 2022 Jul 5;14(13):3281. doi: 10.3390/cancers14133281.
Cancer related cognitive impairment (CRCI) is a common and persistent symptom in breast cancer patients. The Attentional Function Index (AFI) is a self-report measure that assesses CRCI. AFI includes three subscales, namely effective action, attentional lapses, and interpersonal effectiveness, that are based on working memory, inhibitory control, and cognitive flexibility. Previously, we identified three classes of patients with distinct CRCI profiles using the AFI total scores. The purpose of this study was to expand our previous work using latent class growth analysis (LCGA), to identify distinct cognitive profiles for each of the AFI subscales in the same sample (i.e., 397 women who were assessed seven times from prior to through to 6 months following breast cancer surgery). For each subscale, parametric and non-parametric statistics were used to determine differences in demographic, clinical, and pre-surgical psychological and physical symptoms among the subgroups. Three-, four-, and two-classes were identified for the effective action, attentional lapses, and interpersonal effectiveness subscales, respectively. Across all three subscales, lower functional status, higher levels of anxiety, depression, fatigue, and sleep disturbance, and worse decrements in energy were associated with worse cognitive performance. These and other modifiable characteristics may be potential targets for personalized interventions for CRCI.
癌症相关认知障碍（CRCI）是乳腺癌患者常见且持续存在的症状。注意力功能指数（AFI）是一种评估CRCI的自我报告测量方法。AFI包括三个分量表，即有效行动、注意力失误和人际效能，它们基于工作记忆、抑制控制和认知灵活性。此前，我们使用AFI总分确定了三类具有不同CRCI特征的患者。本研究的目的是扩展我们之前的工作，使用潜在类别增长分析（LCGA），在同一样本（即397名女性，她们在乳腺癌手术前至术后6个月期间接受了七次评估）中确定每个AFI分量表的不同认知特征。对于每个分量表，使用参数和非参数统计来确定亚组之间在人口统计学、临床以及术前心理和身体症状方面的差异。有效行动、注意力失误和人际效能分量表分别确定了三类、四类和两类。在所有三个分量表中，功能状态较低、焦虑、抑郁、疲劳和睡眠障碍水平较高以及能量下降更严重与较差的认知表现相关。这些以及其他可改变的特征可能是CRCI个性化干预的潜在目标。
