Normandie Univ, UNICAEN, PSL Research University, EPHE, INSERM, CHU de Caen, GIP Cyceron, U1077, Neuropsychologie et Imagerie de la Mémoire Humaine, 14000, Caen, France.
Ligue Contre Le Cancer, Cancer & Cognition Platform, 14076, Caen, France.
Neuropsychol Rev. 2022 Sep;32(3):483-505. doi: 10.1007/s11065-021-09521-4. Epub 2021 Aug 5.
Patients with non-central nervous system (CNS) cancer frequently report cognitive complaints, that are recurrent and affect their quality of life. In order to improve supportive care of these cognitive difficulties, it is important to identify associated factors. Sleep disturbance is a good candidate to study, as patients with non-CNS cancer frequently report sleep disorders, and sleep plays a key role in cognitive functioning. The objective of the present systematic review was to summarize the results of studies evaluating the relationship between cognition and sleep in non-CNS cancer, and to highlight the need for further studies. PubMed [Medline] and Scopus databases were screened from April to November 2020 for studies published in English evaluating the association between cognition and sleep in adults with non-CNS cancer. The characteristics and risk of bias for each of the 30 included studies have been reported. Greater cognitive complaints in patients with non-CNS cancer were related to poorer self-reported sleep quality in almost all studies (n = 22/24). By contrast, around half of the studies reported a significant association between poorer neuropsychological performances and sleep complaints (n = 5/11). The studies were found to have several limitations, such as the lack of a control group, which would have shed the light on the period of occurrence of this association (e.g. after cancer diagnosis or after cancer treatments). Our review also identified factors that may influence the relationship between cognition and sleep. Recommendations are given for improving the methodology of future studies and extending the impact of their results.
非中枢神经系统 (CNS) 癌症患者常报告认知主诉，这些主诉反复发作，影响其生活质量。为了改善对这些认知困难的支持性护理，识别相关因素很重要。睡眠障碍是一个很好的研究对象，因为非 CNS 癌症患者常报告睡眠障碍，而睡眠在认知功能中起着关键作用。本系统综述的目的是总结评估非 CNS 癌症患者认知与睡眠之间关系的研究结果，并强调进一步研究的必要性。2020 年 4 月至 11 月，我们在 PubMed [Medline] 和 Scopus 数据库中筛选了以评估非 CNS 癌症成人认知与睡眠之间关联为目标的英文发表研究。报告了 30 项纳入研究的特征和偏倚风险。在几乎所有研究（n=22/24）中，非 CNS 癌症患者的认知主诉越严重，自我报告的睡眠质量越差。相比之下，约一半的研究报告了神经心理表现与睡眠主诉之间存在显著关联（n=5/11）。研究存在一些局限性，例如缺乏对照组，这将阐明这种关联的发生时期（例如，在癌症诊断后或癌症治疗后）。我们的综述还确定了可能影响认知与睡眠之间关系的因素。提出了改善未来研究方法和扩大其结果影响的建议。
