Department of Global and Community Health, College of Health and Human Services, George Mason University, Fairfax, VA 22030, USA.
Department of Preventive Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Int J Environ Res Public Health. 2022 Jun 30;19(13):8074. doi: 10.3390/ijerph19138074.
Urinary concentrations of several endocrine disrupting chemicals, including phthalate metabolites, bisphenol A (BPA), and benzophenone (BP)-type ultraviolet (UV) filters, have been associated with a longer time-to-pregnancy (TTP). Potential modification of these associations by couple's age has not been studied. TTP was defined as the number of prospectively observed menstrual cycles a couple attempted pregnancy until the occurrence of a human chorionic gonadotropic-detected pregnancy. Urinary concentrations of two BP-type UV filters and three phthalate metabolites were measured at baseline. Fecundability odds ratios (FORs) and 95% confidence intervals (CIs) were estimated for each chemical adjusting for age, body mass index, serum cotinine, creatinine, and accounting for right censoring and left truncation. Models evaluated effect modification between EDC concentrations and TTP by partner's age, dichotomized at 35 years. Separate models were run for male and female partners. No significant effect modification was observed for any EDC for either partner, but data were suggestive of a longer TTP among females aged ≥35 years, particularly for BP-2 (FOR = 0.61, 95% CI 0.36, 1.05) and 4-hydroxybenzophenone (FOR = 0.71, 95% CI: 0.46, 1.09) reflecting 39% and 29% reductions in fecundability, respectively. We saw no evidence of effect modification by couples' age on associations between TTP and urinary phthalate or BPA metabolite concentrations. Across the EDCs we examined, we found little evidence that age modifies TTP-exposure associations.
尿液中几种内分泌干扰化学物质（包括邻苯二甲酸代谢物、双酚 A（BPA）和苯并三唑型紫外线（UV）过滤器）的浓度与妊娠时间（TTP）延长有关。尚未研究这些关联是否受夫妇年龄的影响。TTP 定义为夫妇尝试怀孕的前瞻性观察到的月经周期数，直到人绒毛膜促性腺激素检测到妊娠为止。在基线时测量了两种苯并三唑型 UV 过滤器和三种邻苯二甲酸代谢物的尿液浓度。在调整年龄、体重指数、血清可替宁、肌酐的基础上，估计了每种化学物质的可育性比值比（FOR）和 95%置信区间（CI），并考虑了右删失和左截断。模型通过伴侣年龄（35 岁）评估了 EDC 浓度与 TTP 之间的效应修饰，将其分为两部分。为男性和女性伴侣分别运行了单独的模型。对于任何 EDC，对于任何一方，都没有观察到明显的效应修饰，但数据表明，年龄≥35 岁的女性 TTP 较长，特别是对于 BP-2（FOR = 0.61，95%CI 0.36，1.05）和 4-羟基苯并三唑（FOR = 0.71，95%CI：0.46，1.09），这分别反映了生育能力分别降低 39%和 29%。我们没有发现夫妇年龄对 TTP 与尿液邻苯二甲酸或 BPA 代谢物浓度之间的关联有影响修饰的证据。在我们研究的 EDC 中，我们几乎没有发现年龄会改变 TTP 暴露关联的证据。
