International Centre for Cancer Vaccine Science, University of Gdansk, Ul. Kładki 24, 80-822 Gdansk, Poland.
Department of Thoracic Surgery, Medical University of Gdansk, 80-210 Gdansk, Poland.
Int J Mol Sci. 2022 Jun 24;23(13):7030. doi: 10.3390/ijms23137030.
Natural killer cells are innate lymphocytes with the ability to lyse tumour cells depending on the balance of their activating and inhibiting receptors. Growing numbers of clinical trials show promising results of NK cell-based immunotherapies. Unlike T cells, NK cells can lyse tumour cells independent of antigen presentation, based simply on their activation and inhibition receptors. Various strategies to improve NK cell-based therapies are being developed, all with one goal: to shift the balance to activation. In this review, we discuss the current understanding of ways NK cells can lyse tumour cells and all the inhibitory signals stopping their cytotoxic potential.
自然杀伤细胞是先天淋巴细胞，能够根据其激活和抑制受体的平衡裂解肿瘤细胞。越来越多的临床试验显示 NK 细胞免疫疗法有前景的结果。与 T 细胞不同，NK 细胞可以在不依赖抗原呈递的情况下裂解肿瘤细胞，仅仅基于其激活和抑制受体。正在开发各种策略来改进 NK 细胞疗法，所有这些策略都有一个目标：改变平衡以促进激活。在这篇综述中，我们讨论了目前对 NK 细胞裂解肿瘤细胞的方式以及阻止其细胞毒性潜力的所有抑制信号的理解。
