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Overcoming the challenges in translational development of natural killer cell therapeutics: An opinion paper.

作者信息

Qin Hong, You Changqiao, Yan Feng, Tan Kefang, Xu Changgen, Zhao Rui, Ekpo Marlene Davis, Tan Songwen

机构信息

Research and Development Department, NanHua Bio-medicine CO., Ltd., Changsha, China.

Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China.

出版信息

Front Oncol. 2022 Dec 2;12:1062765. doi: 10.3389/fonc.2022.1062765. eCollection 2022.

DOI:10.3389/fonc.2022.1062765
PMID:36531041
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9755875/
Abstract
摘要

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Reumatologia. 2022;60(4):258-265. doi: 10.5114/reum.2022.119042. Epub 2022 Sep 7.
2
Multifaceted characterization of the biological and transcriptomic signatures of natural killer cells derived from cord blood and placental blood.对源自脐带血和胎盘血的自然杀伤细胞的生物学和转录组特征进行多方面表征。
Cancer Cell Int. 2022 Sep 24;22(1):291. doi: 10.1186/s12935-022-02697-6.
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Cord Blood-Derived Natural Killer Cell Exploitation in Immunotherapy Protocols: More Than a Promise?免疫治疗方案中对脐血来源的自然杀伤细胞的利用:仅仅是一个承诺吗?
Cancers (Basel). 2022 Sep 13;14(18):4439. doi: 10.3390/cancers14184439.
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Enhancing Natural Killer Cell-Mediated Cancer Immunotherapy by the Biological Macromolecule Cell-Wall Skeleton.生物大分子细胞壁骨架增强自然杀伤细胞介导的癌症免疫疗法。
Pathol Oncol Res. 2022 Aug 30;28:1610555. doi: 10.3389/pore.2022.1610555. eCollection 2022.
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enhances natural killer cytolytic activity and anticancer efficacy and .增强自然杀伤细胞的细胞溶解活性和抗癌功效以及。(原英文句子表述似乎不完整)
Front Med (Lausanne). 2022 Aug 18;9:973681. doi: 10.3389/fmed.2022.973681. eCollection 2022.
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Decreased CD57 expression of natural killer cells enhanced cytotoxicity in patients with primary sclerosing cholangitis.原发性硬化性胆管炎患者自然杀伤细胞 CD57 表达降低增强了其细胞毒性。
Front Immunol. 2022 Aug 17;13:912961. doi: 10.3389/fimmu.2022.912961. eCollection 2022.
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Clinical translation of stem cell therapy for spinal cord injury still premature: results from a single-arm meta-analysis based on 62 clinical trials.临床转化中的干细胞治疗脊髓损伤仍不成熟:基于 62 项临床试验的单臂荟萃分析结果。
BMC Med. 2022 Sep 5;20(1):284. doi: 10.1186/s12916-022-02482-2.
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Overcoming tumor resistance mechanisms in CAR-NK cell therapy.克服 CAR-NK 细胞治疗中的肿瘤耐药机制。
Front Immunol. 2022 Aug 3;13:953849. doi: 10.3389/fimmu.2022.953849. eCollection 2022.
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ELK3 modulates the antitumor efficacy of natural killer cells against triple negative breast cancer by regulating mitochondrial dynamics.ELK3 通过调节线粒体动力学调节自然杀伤细胞对三阴性乳腺癌的抗肿瘤疗效。
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