Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wroclaw, Poland.
Department of Pediatrics with Clinical Assessment Unit, Medical University of Warsaw, 02-091 Warsaw, Poland.
Int J Mol Sci. 2022 Jun 26;23(13):7096. doi: 10.3390/ijms23137096.
Skin and gastrointestinal cancer cells are the target of research by many scientists due to the increasing morbidity and mortality rates around the world. New indications for drugs used in various conditions are being discovered. Non-opioid analgesics are worth noting as very popular, widely available, relatively cheap medications. They also have the ability to modulate the membrane components of tumor cells. The aim of this review is to analyze the impact of diclofenac, ibuprofen, naproxen, acetylsalicylic acid and paracetamol on skin and gastrointestinal cancers cell membrane. These drugs may affect the membrane through topical application, at the in vitro and in vivo level after oral or parenteral administration. They can lead to up- or downregulated expression of receptors, transporters and other molecules associated with plasma membrane. Medications may also alter the lipid bilayer composition of membrane, resulting in changes in its integrity and fluidity. Described modulations can cause the visualization of cancer cells, enhanced response of the immune system and the initiation of cell death. The outcome of this is inhibition of progression or reduction of tumor mass and supports chemotherapy. In conclusion, non-opioid analgesics may be used in the future as adjunctive therapy for the treatment of these cancers.
皮肤和胃肠道癌症细胞是许多科学家研究的目标，因为全球的发病率和死亡率都在上升。人们正在发现各种情况下使用的药物的新适应症。非阿片类镇痛药是非常受欢迎、广泛可用、相对便宜的药物，值得注意。它们还具有调节肿瘤细胞膜成分的能力。本综述的目的是分析双氯芬酸、布洛芬、萘普生、乙酰水杨酸和扑热息痛对皮肤和胃肠道癌细胞膜的影响。这些药物可以通过局部应用、口服或肠胃外给药后的体外和体内水平来影响细胞膜。它们可以导致受体、转运体和其他与质膜相关的分子的表达上调或下调。药物还可以改变膜的脂双层组成，导致其完整性和流动性发生变化。所描述的调节可以导致癌细胞可视化、增强免疫系统反应和启动细胞死亡。其结果是抑制进展或减少肿瘤体积并支持化疗。总之，非阿片类镇痛药将来可能被用作这些癌症治疗的辅助疗法。
