Królikowska Agnieszka, Filipska-Blejder Karolina, Jabłońska Renata, Haor Beata, Antczak-Komoterska Anna, Biercewicz Monika, Grzelak Lech, Harat Marek, Ślusarz Robert
Neurological and Neurosurgical Nursing Department, Faculty of Health Science, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Łukasiewicza 1 Street, 85-821 Bydgoszcz, Poland.
Institute of Health Science, The State Vocational University in Włocławek, Obrońców Wisły 1920r. 21/23 Street, 87-800 Włocławek, Poland.
J Clin Med. 2022 Jun 28;11(13):3733. doi: 10.3390/jcm11133733.
Quality of life is one of the parameters that characterize the success of brain tumor treatments, along with overall survival and a disease-free life. Thus, the main aim of this research was to evaluate the quality of life after the surgical treatment of brain tumors. The research material included 236 patients who were to undergo surgery for brain tumors. The participants completed the quality of life questionnaires EORTC QLQ-C30 (version 3.0) and EORTC QLQ-BN20 on the day of admission to the department, on the fifth day after the removal of the brain tumor, and thirty days after the surgical procedure. Descriptive statistics, Student's -test, the Kruskal-Wallis test, the Shapiro-Wolf test, ANOVA, and Fisher's least significant difference post hoc test were performed. The mean score of the questionnaire before the surgical procedure amounted to 0.706, 5 days after surgery it amounted to 0.614, and 30 days after surgery to 0.707. The greatest reduction in the quality of life immediately after the procedure was observed in patients with low-grade glial tumors (WHO I, II) and extracerebral tumors (meningiomas and neuromas). Thirty days after surgery, an improvement in the quality of life was observed in all included groups. The greatest improvement was recorded in the group of patients operated on for meningioma and neuroblastoma, and the lowest in patients treated for metastatic tumors. Contemporary surgical procedures used in neurosurgery reduce the quality of life in patients with brain tumors only in the early postoperative period. Histopathological diagnoses of these tumors impact the quality of life of patients.
生活质量是表征脑肿瘤治疗成功与否的参数之一，与总生存期和无病生存期一样重要。因此，本研究的主要目的是评估脑肿瘤手术治疗后的生活质量。研究材料包括236例即将接受脑肿瘤手术的患者。参与者在入院当天、脑肿瘤切除术后第5天以及手术后30天完成了生活质量问卷EORTC QLQ-C30（第3.0版）和EORTC QLQ-BN20。进行了描述性统计、学生t检验、Kruskal-Wallis检验、Shapiro-Wolf检验、方差分析和Fisher最小显著差异事后检验。手术前问卷的平均得分是0.706，手术后5天是0.614，手术后30天是0.707。在低级别胶质瘤（世界卫生组织I、II级）和脑外肿瘤（脑膜瘤和神经瘤）患者中，术后立即观察到生活质量下降最为明显。手术后30天，所有纳入组的生活质量均有所改善。脑膜瘤和神经母细胞瘤手术患者组的改善最为明显，而转移性肿瘤患者的改善最小。神经外科目前使用的手术方法仅在术后早期会降低脑肿瘤患者的生活质量。这些肿瘤的组织病理学诊断会影响患者的生活质量。
