Du Peng, Chen Hongyi, Lv Kun, Geng Daoying
Department of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Center for Shanghai Intelligent Imaging for Critical Brain Diseases Engineering and Technology Research, Shanghai 200433, China.
J Clin Med. 2022 Jun 30;11(13):3802. doi: 10.3390/jcm11133802.
Glioma is the most common primary malignant tumor of the adult central nervous system (CNS), which mostly shows invasive growth. In most cases, surgery is often difficult to completely remove, and the recurrence rate and mortality of patients are high. With the continuous development of molecular genetics and the great progress of molecular biology technology, more and more molecular biomarkers have been proved to have important guiding significance in the individualized diagnosis, treatment, and prognosis evaluation of glioma. With the updates of the World Health Organization (WHO) classification of tumors of the CNS in 2021, the diagnosis and treatment of glioma has entered the era of precision medicine in the true sense. Due to its ability to non-invasively achieve accurate identification of glioma from other intracranial tumors, and to predict the grade, genotyping, treatment response, and prognosis of glioma, which provides a scientific basis for the clinical application of individualized diagnosis and treatment model of glioma, radiomics has become a research hotspot in the field of precision medicine. This paper reviewed the research related to radiomics of adult gliomas published in recent years and summarized the research proceedings of radiomics in differential diagnosis, preoperative grading and genotyping, treatment and efficacy evaluation, and survival prediction of adult gliomas.
胶质瘤是成人中枢神经系统（CNS）最常见的原发性恶性肿瘤，多呈浸润性生长。多数情况下，手术常难以完全切除，患者的复发率和死亡率较高。随着分子遗传学的不断发展和分子生物学技术的巨大进步，越来越多的分子生物标志物被证明在胶质瘤的个体化诊断、治疗及预后评估中具有重要指导意义。随着2021年世界卫生组织（WHO）中枢神经系统肿瘤分类的更新，胶质瘤的诊断和治疗真正进入了精准医学时代。由于放射组学能够非侵入性地实现从其他颅内肿瘤中准确识别胶质瘤，并预测胶质瘤的分级、基因分型、治疗反应及预后，为胶质瘤个体化诊断和治疗模式的临床应用提供了科学依据，因此放射组学已成为精准医学领域的研究热点。本文综述了近年来发表的关于成人胶质瘤放射组学的相关研究，并总结了放射组学在成人胶质瘤鉴别诊断、术前分级和基因分型、治疗及疗效评估以及生存预测方面的研究进展。
