Franczak Justyna, Moppert Justyna, Sobolewska-Pilarczyk Małgorzata, Pawłowska Małgorzata
Department of Paediatrics, Infectious Diseases and Hepatology, Voivodeship Infectious Observation Hospital in Bydgoszcz, 85-030 Bydgoszcz, Poland.
Department of Infectious Diseases and Hepatology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 87-100 Toruń, Poland.
J Clin Med. 2022 Jul 1;11(13):3819. doi: 10.3390/jcm11133819.
The aim of the study was to assess the seroprevalence of SARS-CoV-2 IgG antibodies in children hospitalized for reasons other than COVID-19. The study was conducted among 686 children, aged 2 weeks to 18 years, hospitalized in the Department of Paediatrics, Infectious Diseases, and Hepatology in Bydgoszcz, Poland, in the period from 1 June 2021 to 30 April 2022. The presence of anti-SARS-CoV-2 antibodies was detected in 392 (57%) children. Since December 2021, a significantly larger proportion of children with a positive titer of anti-SARS-CoV-2 antibodies has been observed, constituting as much as 87.5% of patients hospitalized in April 2022. In total, 69% of children with detected anti-SARS-CoV-2 antibodies were children under 5 years of age. The highest mean amounts of titers of anti-SARS-CoV-2 antibodies were observed in children over 10 years of age. The conducted studies showed the presence of anti-SARS-CoV-2 antibodies in a significant group of hospitalized children and an increase in the percentage of these children during the fourth and fifth wave of COVID-19 in Poland caused by the Delta and Omicron variants, respectively. The vast majority of parents of the studied children had no knowledge of the COVID-19 infection in their charges, which may indicate asymptomatic infection or mild course of the disease.
该研究的目的是评估因非新冠病毒疾病住院的儿童中新冠病毒2型免疫球蛋白G（SARS-CoV-2 IgG）抗体的血清流行率。该研究在2021年6月1日至2022年4月30日期间，对波兰比得哥什市儿科、传染病和肝病科收治的686名年龄在2周至18岁的儿童进行。在392名（57%）儿童中检测到抗SARS-CoV-2抗体。自2021年12月以来，观察到抗SARS-CoV-2抗体滴度呈阳性的儿童比例显著增加，在2022年4月住院的患者中占比高达87.5%。在检测到抗SARS-CoV-2抗体的儿童中，共有69%为5岁以下儿童。10岁以上儿童的抗SARS-CoV-2抗体平均滴度最高。所开展的研究表明，在一组住院儿童中存在抗SARS-CoV-2抗体，并且在波兰分别由德尔塔和奥密克戎变种引发的新冠疫情第四波和第五波期间，这些儿童的比例有所增加。所研究儿童的绝大多数家长对其子女感染新冠病毒并不知情，这可能表明存在无症状感染或疾病病程较轻。
