Roth Sebastian, M'Pembele René, Nucaro Anthony, Stroda Alexandra, Tenge Theresa, Lurati Buse Giovanna, Sixt Stephan U, Westenfeld Ralf, Rellecke Philipp, Tudorache Igor, Hollmann Markus W, Aubin Hug, Akhyari Payam, Lichtenberg Artur, Huhn Ragnar, Boeken Udo
Department of Anesthesiology, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.
Department of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.
J Clin Med. 2022 Jul 3;11(13):3853. doi: 10.3390/jcm11133853.
The number of patients waiting for heart transplantation (HTX) is increasing. Optimizing the use of all available donor hearts is crucial. While mortality seems not to be affected by donor cardiopulmonary resuscitation (CPR), the impact of donor CPR on days alive and out of hospital (DAOH) is unclear.
This retrospective study included adults who underwent HTX at the University Hospital Duesseldorf, Germany from 2010-2020. Main exposure was donor-CPR. Secondary exposure was the length of CPR. The primary endpoint was DAOH at one year.
A total of 187 patients were screened and 171 patients remained for statistical analysis. One-year mortality was 18.7%. The median DAOH at one year was 295 days (interquartile range 206-322 days). Forty-two patients (24.6%) received donor-CPR hearts. The median length of CPR was 15 (9-21) minutes. There was no significant difference in DAOH between patients with donor-CPR hearts versus patients with no-CPR hearts (CPR: 291 days (211-318 days) vs. no-CPR: 295 days (215-324 days); = 0.619). Multivariate linear regression revealed that there was no association between length of CPR and DAOH (unstandardized coefficients B: -0.06, standard error: 0.81, 95% CI -1.65-1.53, = 0.943).
Donor CPR status and length of CPR are not associated with reduced DAOH at one year after HTX.
等待心脏移植（HTX）的患者数量正在增加。优化所有可用供体心脏的使用至关重要。虽然供体心肺复苏（CPR）似乎不影响死亡率，但供体CPR对存活出院天数（DAOH）的影响尚不清楚。
这项回顾性研究纳入了2010年至2020年在德国杜塞尔多夫大学医院接受HTX的成年人。主要暴露因素是供体CPR。次要暴露因素是CPR持续时间。主要终点是1年时的DAOH。
共筛选出187例患者，171例患者纳入统计分析。1年死亡率为18.7%。1年时DAOH的中位数为295天（四分位间距206 - 322天）。42例患者（24.6%）接受了供体CPR后的心脏。CPR的中位数持续时间为15（9 - 21）分钟。接受供体CPR心脏的患者与未接受CPR心脏的患者在DAOH方面无显著差异（CPR：291天（211 - 318天） vs. 未接受CPR：295天（215 - 324天）；P = 0.619）。多变量线性回归显示，CPR持续时间与DAOH之间无关联（未标准化系数B： - 0.06，标准误：0.81，95%CI - 1.65 - 1.53，P = 0.943）。
供体CPR状态和CPR持续时间与HTX后1年时DAOH的降低无关。
