新型共轭物-(对芳基三唑基)-1,5-苯并二氮杂*-2-酮的区域选择性一锅法合成、生物活性及分子对接研究，作为有效的抗菌和抗真菌试剂。
Regioselective One-Pot Synthesis, Biological Activity and Molecular Docking Studies of Novel Conjugates -(p-Aryltriazolyl)-1,5-benzodiazepin-2-ones as Potent Antibacterial and Antifungal Agents.
机构信息
Laboratory of Heterocyclic Chemistry Natural Products and Reactivity/CHPNR, Department of Chemistry, Faculty of Science of Monastir, University of Monastir, Monastir 5000, Tunisia.
Department of Chemistry, College of Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.
出版信息
Molecules. 2022 Jun 22;27(13):4015. doi: 10.3390/molecules27134015.
Novel 1,2,3-triazolo-linked-1,5-benzodiazepinones were designed and synthesized via a Cu(I)-catalyzed 1,3-dipolar alkyne-azide coupling reaction (CuAAC). The chemical structures of these compounds were confirmed by H NMR, C NMR, HMBC, HRMS, and elemental analysis. The compounds were screened for their in vitro antibacterial and antifungal activities. Several compounds exhibited good to moderate activities compared to those of established standard drugs. Furthermore, the binding interactions of these active analogs were confirmed through molecular docking.
新型 1,2,3-三唑并连接的 1,5-苯并二氮杂卓通过 Cu(I)-催化的 1,3-偶极炔烃-叠氮化物偶联反应 (CuAAC) 设计和合成。通过 H NMR、C NMR、HMBC、HRMS 和元素分析确认了这些化合物的化学结构。对这些化合物进行了体外抗菌和抗真菌活性筛选。与标准药物相比，几种化合物表现出良好至中等的活性。此外，通过分子对接证实了这些活性类似物的结合相互作用。
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