Department of Applied Chemistry, Kyushu Institute of Technology, Fukuoka 804-8550, Japan.
Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, Fukuoka 820-8502, Japan.
Molecules. 2022 Jun 23;27(13):4053. doi: 10.3390/molecules27134053.
Newly synthesized naphthalene diimide carrying two β-cyclodextrins (NDI-β-CyDs) showed improved specificity for the parallel G-quadruplex structure alongside the hybrid G-quadruplex structure. Specifically, the highest binding affinity of NDI-β-CyDs for the telomere RNA G-quadruplex was observed. The binding simulation indicated that β-cyclodextrins might be available for loop nucleobase inclusion under its complex.
新合成的带有两个 β-环糊精的萘二酰亚胺（NDI-β-CyDs）显示出对平行 G-四链体结构以及杂交 G-四链体结构的特异性提高。具体来说，观察到 NDI-β-CyDs 与端粒 RNA G-四链体的最高结合亲和力。结合模拟表明，β-环糊精在其复合物下可能可用于环碱基包含。
