孕晚期开始时母体白细胞锌缺乏作为胎儿生长迟缓的预测指标。
Maternal leucocyte zinc deficiency at start of third trimester as a predictor of fetal growth retardation.
作者信息
Wells J L, James D K, Luxton R, Pennock C A
出版信息
Br Med J (Clin Res Ed). 1987 Apr 25;294(6579):1054-6. doi: 10.1136/bmj.294.6579.1054.
Leucocyte zinc concentrations were measured in 70 mothers at the beginning of the third trimester of pregnancy and compared with the weight centiles of their subsequently delivered babies. The median maternal leucocyte zinc concentrations rose progressively with weight centile. Thus the median leucocyte zinc concentration of the mothers delivering babies weighing below the 10th centile was 112 nmol/10(9) leucocytes and that of the mothers with babies weighing above the 90th centile was 229.5 nmol/10(9) leucocytes. A maternal leucocyte zinc concentration less than 120 nmol/10(9) leucocytes strongly predicted a baby weighing below the 10th centile (positive predictive value = 71.9%, negative predictive value = 91.5%, sensitivity = 64.3%, specificity = 81.8%). These findings suggest that maternal zinc concentration might have a role in antenatal screening, but larger studies are required.
在70名孕妇妊娠晚期开始时测量了白细胞锌浓度，并将其与她们随后分娩婴儿的体重百分位数进行比较。母亲白细胞锌浓度中位数随体重百分位数逐渐升高。因此，分娩体重低于第10百分位数婴儿的母亲，其白细胞锌浓度中位数为112纳摩尔/10⁹白细胞，而分娩体重高于第90百分位数婴儿的母亲，其白细胞锌浓度中位数为229.5纳摩尔/10⁹白细胞。母亲白细胞锌浓度低于120纳摩尔/10⁹白细胞强烈预示婴儿体重低于第10百分位数（阳性预测值 = 71.9%，阴性预测值 = 91.5%，敏感性 = 64.3%，特异性 = 81.8%）。这些发现表明母亲锌浓度可能在产前筛查中起作用，但需要更大规模的研究。
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