Mahomed K, James D K, Golding J, McCabe R
University Department of Obstetrics and Gynaecology, Avondale, Harare, Zimbabwe.
BMJ. 1989 Sep 30;299(6703):826-30. doi: 10.1136/bmj.299.6703.826.
To see whether zinc supplementation during pregnancy improves maternal and fetal outcome.
Prospective study started at booking and continued till discharge of mother and baby from the maternity hospital. Mothers were randomly assigned to receive zinc supplementation or placebo in a double blind trial.
Mothers booking at one hospital.
Women booking before 20 weeks of gestation who agreed to take part in the study. 494 Mothers were followed up till the end of pregnancy. There was no difference between the groups given zinc and placebo in their social or medical backgrounds.
Mothers in the active treatment group received one capsule of 20 mg elemental zinc daily and those in the placebo treated group a capsule identical in appearance and taste with the active capsule but which contained inert substances.
Various adverse outcomes were tested, including maternal bleeding, hypertension, complications of labour and delivery, gestational age, Apgar scores, and neonatal abnormalities. The main outcome measure was birth weight.
There were no differences whatsoever between mothers given a zinc supplement and those given a placebo.
Zinc supplementation in pregnancy in the United Kingdom does not seem to offer any benefits to the mother or her fetus.
观察孕期补充锌是否能改善母婴结局。
前瞻性研究，从登记开始，持续至母婴从妇产医院出院。在双盲试验中，母亲们被随机分配接受锌补充剂或安慰剂。
在一家医院登记的母亲。
妊娠20周前登记并同意参与研究的妇女。494名母亲被随访至妊娠结束。给予锌和安慰剂的两组在社会或医学背景方面无差异。
积极治疗组的母亲每天服用一粒含20毫克元素锌的胶囊，安慰剂治疗组的母亲服用一粒外观和味道与活性胶囊相同但含有惰性物质的胶囊。
检测了各种不良结局，包括母亲出血、高血压、分娩并发症、孕周、阿氏评分和新生儿异常。主要结局指标是出生体重。
服用锌补充剂的母亲和服用安慰剂的母亲之间没有任何差异。
在英国，孕期补充锌似乎对母亲或其胎儿没有任何益处。
