Little R E, Streissguth A P, Barr H M, Herman C S
J Pediatr. 1980 Jun;96(6):974-7. doi: 10.1016/s0022-3476(80)80620-2.
Fifty infants born to women who reported total abstinence during pregnancy, but who had a history of alcoholism prior to conception, were compared to 50 infants born to alcoholic women who reported drinking heavily during pregnancy, and to 50 infants of nonalcoholic controls. Mean birth weight of infants born to the abstinent alcoholics was 258 gm less than mean birth weight of the control infants. Infants of drinking alcoholics weighed 493 gm less than the control infants. These differences in offspring birth weight were statistically significant after adjusting for maternal smoking, height, age, and parity, as well as gestational age and sex of child. This finding suggests that a history of maternal alcoholism may pose a risk to fetal growth independent of alcohol use during the pregnancy.
将50名母亲在孕期报告完全戒酒，但在怀孕前有酗酒史的婴儿，与50名母亲为酗酒者且在孕期报告大量饮酒的婴儿，以及50名非酗酒对照组的婴儿进行比较。戒酒的酗酒者所生婴儿的平均出生体重比对照组婴儿的平均出生体重轻258克。饮酒的酗酒者所生婴儿比对照组婴儿轻493克。在对母亲的吸烟情况、身高、年龄、产次以及孕周和孩子性别进行调整后，这些后代出生体重的差异具有统计学意义。这一发现表明，母亲酗酒史可能对胎儿生长构成风险，而与孕期饮酒无关。
