Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
J Clin Lab Anal. 2022 Aug;36(8):e24585. doi: 10.1002/jcla.24585. Epub 2022 Jul 8.
Colorectal cancer (CRC) with a high prevalence is recognized as the fourth most common cause of cancer-related death globally. Over the past decade, there has been growing interest in the network of tumor cells, stromal cells, immune cells, blood vessel cells, and fibroblasts that comprise the tumor microenvironment (TME) to identify new therapeutic interventions.
Databases, such as Google Scholar, PubMed, and Scopus, were searched to provide an overview of the recent research progress related to targeting the TME as a novel therapeutic approach.
Tumor microenvironment as a result of the cross talk between these cells may result in either advantages or disadvantages in tumor development and metastasis, affecting the signals and responses from the surrounding cells. Whilst chemotherapy has led to an improvement in CRC patients' survival, the metastatic aspect of the disease remains difficult to avoid.
The present review emphasizes the structure and function of the TME, alterations in the TME, its role in the incidence and progression of CRC, the effects on tumor development and metastasis, and also the potential of its alterations as therapeutic targets. It should be noted that providing novel studies in this field of research might help us to achieve practical therapeutic strategies based on their interaction.
结直肠癌（CRC）的发病率较高，被认为是全球第四大常见的癌症相关死亡原因。在过去的十年中，人们对肿瘤细胞、基质细胞、免疫细胞、血管细胞和成纤维细胞组成的肿瘤微环境（TME）网络越来越感兴趣，以期找到新的治疗干预方法。
通过 Google Scholar、PubMed 和 Scopus 等数据库搜索，提供了有关针对 TME 作为一种新的治疗方法的最新研究进展概述。
这些细胞之间的相互作用导致肿瘤微环境可能在肿瘤的发展和转移中产生优势或劣势，影响周围细胞的信号和反应。虽然化疗已导致 CRC 患者的生存率提高，但该疾病的转移方面仍难以避免。
本综述强调了 TME 的结构和功能、TME 的改变、其在 CRC 的发生和进展中的作用、对肿瘤发展和转移的影响，以及其改变作为治疗靶点的潜力。值得注意的是，在该研究领域提供新的研究可能有助于我们根据它们的相互作用实现实用的治疗策略。
