Wan Jinlong, Zhao Jianzhong, Fang Xiaolu
Department of Gastroenterology, Gaozhou People's Hospital, Maoming, China.
Department of Clinical Laboratory, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, China.
Front Immunol. 2024 Nov 29;15:1502257. doi: 10.3389/fimmu.2024.1502257. eCollection 2024.
Colorectal cancer (CRC) is one of the most significant oncological threats to human health globally. Patients often exhibit a high propensity for tumor recurrence and metastasis post-surgery, resulting in suboptimal prognoses. One of the underlying reasons for the metastatic potential of CRC is the sustained abnormal state of the tumor immune microenvironment, particularly characterized by the atypical death of critical immune cells. In recent years, a novel concept of cell death known as PANoptosis has emerged. This form of cell death is regulated by the PANoptosome complex and encompasses key features of apoptosis, pyroptosis, and necroptosis, yet cannot be entirely substituted by any of these processes alone. Due to its widespread occurrence and complex mechanisms, PANoptosis has been increasingly reported in various malignancies, enhancing our understanding of its pathological mechanisms, particularly in the context of CRC. However, the characteristics of immune cell PANoptosis within the CRC immune microenvironment have not been thoroughly elucidated. In this review, we focus on the impact of CRC progression on various immune cell types and summarize the distinctive features of immune cell PANoptosis. Furthermore, we highlight the future research trends and challenges associated with the mechanisms of immune cell PANoptosis in CRC.
结直肠癌（CRC）是全球对人类健康构成重大威胁的肿瘤之一。患者术后往往具有较高的肿瘤复发和转移倾向，导致预后不理想。CRC具有转移潜能的一个根本原因是肿瘤免疫微环境持续处于异常状态，其特征尤其表现为关键免疫细胞的非典型死亡。近年来，一种名为PANoptosis的新型细胞死亡概念出现了。这种细胞死亡形式由PANoptosome复合体调控，包含凋亡、焦亡和坏死性凋亡的关键特征，但不能被这些过程中的任何一个单独完全替代。由于其广泛存在且机制复杂，PANoptosis在各种恶性肿瘤中越来越多地被报道，这增进了我们对其病理机制的理解，尤其是在CRC背景下。然而，CRC免疫微环境中免疫细胞PANoptosis的特征尚未得到充分阐明。在本综述中，我们重点关注CRC进展对各种免疫细胞类型的影响，并总结免疫细胞PANoptosis的独特特征。此外，我们强调了与CRC中免疫细胞PANoptosis机制相关的未来研究趋势和挑战。
