Department of Orthopaedic, Trauma, and Reconstructive Surgery, RWTH University Hospital, Pauwelsstraße 30, 52074, Aachen, Germany.
Department of Medicine, Surgery and Dentistry, University of Salerno, 84081, Baronissi, SA, Italy.
J Orthop Traumatol. 2022 Jul 9;23(1):30. doi: 10.1186/s10195-022-00646-7.
Some patients have demonstrated evidence of heterotopic ossification (HO) following total hip arthroplasty (THA). Selective and non-selective non-steroidal anti-inflammatory drugs (NSAIDs) are used as prophylaxis for HO following THA. This meta-analysis compared selective versus non-selective NSAIDs as prophylaxis for HO following THA.
The present study was conducted according to the PRISMA 2020 guidelines. All the clinical investigations comparing selective versus non-selective NSAIDs as prophylaxis for HO following THA were accessed in February 2022. An assessment of the methodological quality and statistical analyses were performed through the risk of bias summary tool of the Review Manager 5.3 software (Cochrane Collaboration, Copenhagen). The modified Brooker staging system was used to rate the efficacies of the interventions.
Data from 8 studies and 1526 patients were collected. 60.8% were female. No difference was found in the sample size, mean age, and percentage of females between the two groups at baseline. No statistically significant difference was found between selective and non-selective NSAIDs in term of efficacy. 72% (1078 of 1502) of the patients were classified as Brooker 0, 21% (322 of 1502) as Brooker I, 5% (80 of 1502) as Brooker II, 1% (16 of 1502) as Brooker III, and 0.1% (2 of 1502) as Brooker IV.
Selective and non-selective NSAIDs were equally effective when used as prophylaxis for HO following THA.
Level III, systematic review and meta-analysis.
一些患者在全髋关节置换术后（THA）出现了异位骨化（HO）的证据。选择性和非选择性非甾体抗炎药（NSAIDs）被用于预防 THA 后 HO 的发生。本荟萃分析比较了选择性与非选择性 NSAIDs 作为 THA 后 HO 预防的效果。
本研究根据 PRISMA 2020 指南进行。所有比较选择性与非选择性 NSAIDs 作为 THA 后 HO 预防的临床研究均于 2022 年 2 月进行检索。通过 Review Manager 5.3 软件（Cochrane 协作，哥本哈根）的风险偏倚摘要工具对方法学质量和统计分析进行评估。改良的布鲁克分期系统用于评估干预措施的疗效。
共纳入 8 项研究和 1526 例患者的数据。女性占 60.8%。两组患者在基线时的样本量、平均年龄和女性比例均无差异。选择性和非选择性 NSAIDs 在疗效方面无统计学差异。72%（1078/1502）的患者为布鲁克 0 期，21%（322/1502）为布鲁克 I 期，5%（80/1502）为布鲁克 II 期，1%（16/1502）为布鲁克 III 期，0.1%（2/1502）为布鲁克 IV 期。
选择性和非选择性 NSAIDs 作为 THA 后 HO 的预防措施同样有效。
III 级，系统评价和荟萃分析。
