Wu Chenhua, Tao Yingjun, Li Nan, Fei Jingjin, Wang Yurong, Wu Jie, Gu Harvest F
Laboratory of Molecular Medicine, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Laboratory of Minigene Pharmacy, School of Life Science and Technology, China Pharmaceutical University, Nanjing, 211198, China.
J Cell Commun Signal. 2023 Mar;17(1):169-188. doi: 10.1007/s12079-022-00685-z. Epub 2022 Jul 9.
Diabetic kidney disease is the leading cause of impaired kidney function, albuminuria, and renal replacement therapy (dialysis or transplantation), thus placing a large burden on health-care systems. This urgent event requires us to reveal the molecular mechanism of this disease to develop more efficacious treatment. Herein, we reported single-cell RNA sequencing analyses in kidneys of db/db mouse, an animal model for type 2 diabetes and diabetic kidney disease. We first analyzed the hub genes expressed differentially in the single cell resolution transcriptome map of the kidneys. Then we figured out the communication among the renal and immune cells in the kidneys. Data from this report may provide novel information for better understanding the cell-specific targets involved in the aetiologia of type 2 diabetic kidney disease and for cell communication and signaling between renal cells and immune cells of this complex disease.
糖尿病肾病是肾功能受损、蛋白尿和肾脏替代治疗（透析或移植）的主要原因，给医疗保健系统带来了沉重负担。这一紧急情况要求我们揭示该疾病的分子机制，以开发更有效的治疗方法。在此，我们报告了对db/db小鼠肾脏进行的单细胞RNA测序分析，db/db小鼠是2型糖尿病和糖尿病肾病的动物模型。我们首先分析了在肾脏单细胞分辨率转录组图谱中差异表达的枢纽基因。然后我们弄清楚了肾脏中肾细胞和免疫细胞之间的通讯。本报告的数据可能为更好地理解2型糖尿病肾病病因中涉及的细胞特异性靶点以及这种复杂疾病的肾细胞与免疫细胞之间的细胞通讯和信号传导提供新信息。
