临床之星转角：老年病学和肾脏病学的界面有哪些新进展？
Clin-Star corner: What is new at the interface of geriatrics and nephrology?
机构信息
Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Vanderbilt O'Brien Center for Kidney Disease, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
出版信息
J Am Geriatr Soc. 2022 Aug;70(8):2219-2224. doi: 10.1111/jgs.17942. Epub 2022 Jul 9.
Abstract
Chronic kidney disease (CKD) is prevalent and burdensome among older adults in the United States. CKD affects at least 15% of the US population, and adults over 65 comprise the largest subset within this group. In this special article, we highlight key findings of three recent original investigations in nephrology and describe each study, relevance to the care of older adults, and current areas of uncertainty that warrant further investigation. Articles relate to removal of the race adjustment in the estimation of kidney function, the use of novel therapeutics to halt CKD progression and improve cardiovascular outcomes, and medication management for short-term pain control in CKD.
摘要
慢性肾脏病（CKD）在美国老年人中普遍存在且负担沉重。CKD 至少影响了美国 15%的人口，而 65 岁以上的成年人是这一人群中最大的一部分。在这篇特别文章中，我们重点介绍了肾脏病学最近三项原始研究的主要发现，并描述了每一项研究与老年患者护理的相关性，以及目前需要进一步研究的不确定性领域。这些文章涉及到在估计肾功能时去除种族调整、使用新型治疗方法来阻止 CKD 进展和改善心血管结局，以及 CKD 短期疼痛控制的药物管理。
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本文引用的文献
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A Unifying Approach for GFR Estimation: Recommendations of the NKF-ASN Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Disease.一种用于 GFR 估计的统一方法：NKF-ASN 工作组关于重新评估种族在诊断肾脏疾病中的纳入的建议。
J Am Soc Nephrol. 2021 Dec 1;32(12):2994-3015. doi: 10.1681/ASN.2021070988.
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New Creatinine- and Cystatin C-Based Equations to Estimate GFR without Race.新型基于肌酐和胱抑素 C 的估算肾小球滤过率方程，无需考虑种族因素。
N Engl J Med. 2021 Nov 4;385(19):1737-1749. doi: 10.1056/NEJMoa2102953. Epub 2021 Sep 23.
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JAMA Intern Med. 2021 Oct 1;181(10):1359-1366. doi: 10.1001/jamainternmed.2021.4813.
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J Am Soc Nephrol. 2021 Jun 1;32(6):1454-1463. doi: 10.1681/ASN.2020121780. Epub 2021 May 6.
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