Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Greece.
Rheumatology Unit, University of Perugia, Italy.
Clin Exp Rheumatol. 2018 May-Jun;36 Suppl 112(3):14-26. Epub 2018 Jul 18.
Sjögren's syndrome is a complex and potentially disabling slow progressive, systemic disorder. During the last twelve months several original and important contributions have been published on the pathogenesis, diagnosis and therapy of the disease. This review, following the others of this series is aimed at summarising some of the most significant studies that have been recently published. Regarding the pathogenesis, we will specifically focus on novel insights on miRNA, gut microbiota, adaptive and innate autoimmunity and animal models. Concerning novelties in pSS diagnosis, we will focus on salivary gland ultrasonography and histology. Finally, we will conclude with an update of the clinical manifestations of the disease and with an overview of the future therapies.
干燥综合征是一种复杂且潜在致残的慢性进行性全身性疾病。在过去的 12 个月中，已经发表了许多关于该疾病发病机制、诊断和治疗的原创性和重要的贡献。这篇综述是本系列的后续，旨在总结最近发表的一些最重要的研究。关于发病机制，我们将特别关注 miRNA、肠道微生物群、适应性和固有自身免疫以及动物模型方面的新见解。关于 pSS 诊断的新进展，我们将重点介绍唾液腺超声检查和组织学。最后，我们将更新疾病的临床表现，并概述未来的治疗方法。
