Department of Clinical Pharmacy, College of Pharmacy, Jazan University, Jazan 45142, Kingdom of Saudi Arabia.
Cell Mol Biol (Noisy-le-grand). 2022 Jan 2;67(4):248-263. doi: 10.14715/cmb/2021.67.4.28.
Adhatoda vasica (L.), Nees belonging to the family Acanthaceae is a shrub with opposite ascending branches. The plant has been used in the indigenous system of medicine in India for near about 2500 years. It is a well-known plant as a drug in Ayurvedic and Unani medicines. Traditionally it was used for the treatment of various acute and chronic diseases and showed strong pharmacological activity particularly for bronchial infections, cough, bacterial infections, reproductive disorders, cardiac diseases and many more. Various phytochemicals like alkaloids, flavonoids, tannins, etc. were obtained from Adhatoda vasica (A. vasica). The active constituent of the plant is vasicine, l-vasicinone, deoxyvasicine, maiontone, vasicinolone and vasicinol etc. This review consists of updated information on the phyto-constituents isolated from A. vasica and their potential role in the treatment of various ailments traditionally and medically. Based on the critical review it was concluded that there is not sufficient scientifically strong evidence to explain that A. vasica extract, could be harmful to human beings especially in pregnant women. Major data on traditional uses as well as toxicological studies, evaluated various correctness, relevance, importance, and reliability for the overall evaluation of A. vasica safety. Numerous clinical trials are conducted around the globe on the herbal formulations of vasaka. This review includes strong data about phytochemical and ethnopharmacological studies that indicate that A. vasica is a versatile native plant of the Indian subcontinent having a commercial reputation and thus can be encouraged for diversified applications like medicinal and other potential uses.
印度瓦氏紫菀（Adhatoda vasica（L.），Nees）属于爵床科，是一种具有对生上升枝的灌木。该植物在印度传统医学系统中已使用了大约 2500 年。它是阿育吠陀和顺势疗法药物中著名的植物药。传统上，它被用于治疗各种急性和慢性疾病，并表现出很强的药理活性，特别是对支气管感染、咳嗽、细菌感染、生殖障碍、心脏病等。从印度瓦氏紫菀（A. vasica）中获得了各种植物化学物质，如生物碱、类黄酮、单宁等。该植物的活性成分是瓦氏碱、l-瓦氏辛酮、脱氧瓦氏辛碱、马翁酮、瓦氏辛醇和瓦氏辛醇等。本综述包括了从 A. vasica 中分离出的植物化学成分及其在传统和医学上治疗各种疾病的潜在作用的最新信息。基于批判性评价，没有足够的科学证据表明 A. vasica 提取物对人类，特别是孕妇有害。关于传统用途和毒理学研究的主要数据，评估了 A. vasica 安全性的整体评估的各种正确性、相关性、重要性和可靠性。全球范围内对瓦萨卡的草药配方进行了大量临床试验。本综述包括了关于植物化学和民族药理学研究的有力数据，这些数据表明 A. vasica 是印度次大陆一种用途广泛的本地植物，具有商业声誉，因此可以鼓励其在药用和其他潜在用途方面的多样化应用。
