Biology Department, College of Education, Salahaddin University-Erbil, Kurdistan Region-Iraq.
College of Dentistry, Hawler Medical University, Erbil, Kurdistan Region-Iraq.
Cell Mol Biol (Noisy-le-grand). 2022 Jan 2;67(4):203-213. doi: 10.14715/cmb/2021.67.4.23.
Urinary tract infection (UTI) is a major clinical problem in a wide age range that is associated with a high morbidity rate. Due to issues such as low specificity and the inability to differentiate between different types of infection in current diagnostic methods, there is a need to introduce novel UTI markers. The present study was conducted to evaluate the utility of Procalcitonin (PCT) and interleukin-6 (IL-6) as a marker of bacterial urinary tract infection. For this purpose, a cross-sectional study was conducted between November 2020 and February 2021 among 125 patients and 60 healthy volunteers (control) in Erbil Teaching Hospital. The concentration of PCT and IL-6 was quantified using the ELISA cloud immunoassay test. Between-group comparisons were assessed for the variables with analysis of variance. The results revealed that there was a significant difference between PCT levels in UTI patients (104.6±6.07) and control groups (54±2.24) (p <0.0001). The differences in IL-6 concentration in UTI patients (55.74±4.2) and control groups (24.56±2.4) were also significant (p <0.0001), implying that the level of both PCT and IL-6 increased due to bacterial infection in the urinary tract. As a whole, the findings of this study provide.
尿路感染（UTI）是一个广泛年龄段的主要临床问题，与高发病率有关。由于目前诊断方法的特异性低，无法区分不同类型的感染等问题，因此需要引入新的 UTI 标志物。本研究旨在评估降钙素原（PCT）和白细胞介素-6（IL-6）作为细菌尿路感染标志物的效用。为此，2020 年 11 月至 2021 年 2 月，在埃尔比勒教学医院对 125 名患者和 60 名健康志愿者（对照组）进行了横断面研究。采用 ELISA 云免疫分析试验定量检测 PCT 和 IL-6 的浓度。使用方差分析评估组间变量的比较。结果显示，UTI 患者（104.6±6.07）和对照组（54±2.24）之间的 PCT 水平存在显著差异（p<0.0001）。UTI 患者（55.74±4.2）和对照组（24.56±2.4）之间的 IL-6 浓度差异也具有统计学意义（p<0.0001），这意味着 PCT 和 IL-6 的水平均因尿路感染中的细菌感染而升高。总的来说，本研究的结果表明。
