用于生物分离的纤维素基色谱介质的制备：综述。
Preparation of cellulose-based chromatographic medium for biological separation: A review.
机构信息
Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural Affairs, Sichuan Engineering and Technology Research Center of Coarse Cereal Industralizationa, School of Food and Biological Engineering, Chengdu University, Chengdu 610106, PR China.
Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural Affairs, Sichuan Engineering and Technology Research Center of Coarse Cereal Industralizationa, School of Food and Biological Engineering, Chengdu University, Chengdu 610106, PR China.
出版信息
J Chromatogr A. 2022 Aug 16;1677:463297. doi: 10.1016/j.chroma.2022.463297. Epub 2022 Jul 2.
Cellulose is a kind of renewable linear polysaccharide with good safety, hydrophilicity, biocompatibility and biodegradability and has become a commonly used chromatographic medium for biological separation and purification. The purpose of this paper is to describe the recent developments in the applications of cellulose-based absorbents as chromatographic medium. This review also attempts to explain the current situation of cellulose-based chromatographic medium from the aspects of cellulose dissolution, common strategies for generating spherical particles of cellulose and its derivatives (such as titration, emulsification, microfluidic and other synthesis methods) and improvement of adsorption properties. Furthermore, non-spherical cellulose-based chromatographic medium are also described briefly.
纤维素是一种可再生的线性多糖，具有良好的安全性、亲水性、生物相容性和可生物降解性，已成为生物分离和纯化中常用的色谱介质。本文旨在描述纤维素基吸附剂作为色谱介质的最新应用进展。本文还试图从纤维素溶解、生成纤维素及其衍生物（如滴定、乳化、微流控等合成方法）的球形颗粒的常见策略以及吸附性能的提高等方面来解释纤维素基色谱介质的现状。此外，还简要描述了非球形纤维素基色谱介质。
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